Partial Methylation is Correlated With Elapse of Time Since Diagnosis
| . | Pattern A . | Pattern B . | P . |
|---|---|---|---|
| . | N = 109 . | N = 39 . | . |
| Age (years) at Dx | 33.5 ± 12.2 | 35.7 ± 17.6 | .219 |
| WBC (109/L) | 32.5 ± 39.4 | 48.3 ± 72.5 | .231 |
| Platelets (109/L) | 468 ± 352 | 489 ± 348 | .223 |
| Blasts in BM (%) | 2.3 ± 2.6 | 2.9 ± 3.2 | .339 |
| BM Basophils and Eosinophils (%) | 6.1 ± 5.4 | 6.6 ± 3.4 | .261 |
| Spleen size (cm below costal margin) | 2.5 ± 4.3 | 4.2 ± 5.2 | .321 |
| Time since Dx (months) | 13.9 ± 18.5 | 29.3 ± 33.8 | .010 |
| Median-7.5 | Median-26 |
| . | Pattern A . | Pattern B . | P . |
|---|---|---|---|
| . | N = 109 . | N = 39 . | . |
| Age (years) at Dx | 33.5 ± 12.2 | 35.7 ± 17.6 | .219 |
| WBC (109/L) | 32.5 ± 39.4 | 48.3 ± 72.5 | .231 |
| Platelets (109/L) | 468 ± 352 | 489 ± 348 | .223 |
| Blasts in BM (%) | 2.3 ± 2.6 | 2.9 ± 3.2 | .339 |
| BM Basophils and Eosinophils (%) | 6.1 ± 5.4 | 6.6 ± 3.4 | .261 |
| Spleen size (cm below costal margin) | 2.5 ± 4.3 | 4.2 ± 5.2 | .321 |
| Time since Dx (months) | 13.9 ± 18.5 | 29.3 ± 33.8 | .010 |
| Median-7.5 | Median-26 |
Clinical parameters and time since diagnosis were compared in pattern B chronic phase samples versus pattern A samples. One hundred nine samples were derived from methylation-pattern A patients; 39 samples from pattern B patients. We incorporated all samples including multiple samples from any particular patient taken in the chronic phase. The clinical parameters (aside from age) relate to the number of samples.
Abbreviations: Dx, diagnosis; WBC, white blood cells.