Table 5. Comparison of Unrelated Donor... | American Society of Hematology

Table 5.

Comparison of Unrelated Donor Umbilical Cord Blood and Unmanipulated Unrelated BM Stem Cell Transplantation in Children

	Demographics
	Median Age (range) in yr	HLA A, B, DR, B1 Match^5-150	HLA A, B, DR, B1 1-Antigen Mismatch	HLA A, B, DR, B1 2- or 3-Antigen Mismatch	Grade II-IV aGVHD	Grade III-IV aGVHD

Unrelated donor umbilical cord blood transplantation	4.1 (0.1-23.5)	8 (19%)	16 (73%)	19 (24%)	57%	9%
Unrelated donor unmanipulated BMT	9.1 (0.5-17.8)	46 (54%)	41 (45%)	1 (1%)	90%	49%

	Demographics
	Median Age (range) in yr	HLA A, B, DR, B1 Match^5-150	HLA A, B, DR, B1 1-Antigen Mismatch	HLA A, B, DR, B1 2- or 3-Antigen Mismatch	Grade II-IV aGVHD	Grade III-IV aGVHD

Unrelated donor umbilical cord blood transplantation	4.1 (0.1-23.5)	8 (19%)	16 (73%)	19 (24%)	57%	9%
Unrelated donor unmanipulated BMT	9.1 (0.5-17.8)	46 (54%)	41 (45%)	1 (1%)	90%	49%

Search and Engraftment

Median ANC ≥500/μL (days)

Median Platelet ≥50,000/μL

Median Nuc Cells/kg Infused (range) × 10⁷

(days)

Unrelated donor umbilical cord blood transplantation

3.7 (0.7-40.0)

Unrelated donor unmanipulated BMT

42 (12-460)

HLA Disparity and Incidence of Acute GvHD

HLA A, B, DR, B1 Match^5-152

Grade II-IV aGVHD (%)

Grade III-IV aGVHD (%)

HLA A, B, DR, B1 1-Antigen Mismatch

Grade II-IV aGVHD (%)

Grade III-IV aGVHD (%)

Unrelated donor umbilical cord blood transplantation

n = 6

33%

16%

n = 14

43%

Unrelated donor unmanipulated BMT

n = 46

83%

37%

n = 41

98%

62%

Data are from previous studies.64,65 67

HLA A, B, DR by serology. HLA DR B1 by high resolution DNA typing.

Forty-four patients excluded from analysis because of earlier discharge, relapse, or death before platelet recovery.

Evaluable for aGVHD.