Comparison of Unrelated Cellular Immunity (T or Mononuclear Cells) Isolated From Cord Blood Versus Adult Peripheral Blood
| . | Immunophenotype . | Mediators . | ||||||
|---|---|---|---|---|---|---|---|---|
| . | CD45 RA+ . | CD45 RO+ . | CD3+ . | CD3− CD8+ . | γIFN . | TNFα . | IL-4 . | IL-6 . |
| Umbilical cord blood MNC versus adult MNC | Increased | Decreased | Decreased | Present in cord only | Decreased | Decreased | Decreased | Decreased |
| . | Immunophenotype . | Mediators . | ||||||
|---|---|---|---|---|---|---|---|---|
| . | CD45 RA+ . | CD45 RO+ . | CD3+ . | CD3− CD8+ . | γIFN . | TNFα . | IL-4 . | IL-6 . |
| Umbilical cord blood MNC versus adult MNC | Increased | Decreased | Decreased | Present in cord only | Decreased | Decreased | Decreased | Decreased |
| Functional Responses | |||||
| NK Activity | LAK Activity | Primary T-Cell Proliferation | Secondary T-Cell Alloantigen Proliferation | Alloantigen Cytotoxicity | |
| Umbilical cord blood MNC versus adult MNC | Normal | Normal | Normal | Decreased | Decreased |
| Functional Responses | |||||
| NK Activity | LAK Activity | Primary T-Cell Proliferation | Secondary T-Cell Alloantigen Proliferation | Alloantigen Cytotoxicity | |
| Umbilical cord blood MNC versus adult MNC | Normal | Normal | Normal | Decreased | Decreased |
Data are from previous studies.39-47
Abbreviations: γIFN, γ interferon; TNFα, tumor necrosis factor α; NK, natural killer; LAK, lymphokine activated killer.