Table 1.

Comparison of Cytotoxicity of Targets by the Anti-C1498 Autologous CTL Line T15 and Allogeneic CTLs In Vitro

TargetsT15DBA
1:1*10:1Anti-B6
100:1
C1498 65.2 91.0 34.0 
(anti-CD8)† 3.2 30.9  
(anti-LFA-1) 3.9 5.5  
C1498 B7-1 65.0 82.8  
EL4 8.3 8.8  
FBL 0 0  
Ly5.1 blasts 0 (15) 9.1 (5.0) 28.2 (7.5) 
Ly5.2 blasts 0 (5.1) 8.1 (8.2) 37.9 (7.5) 
TargetsT15DBA
1:1*10:1Anti-B6
100:1
C1498 65.2 91.0 34.0 
(anti-CD8)† 3.2 30.9  
(anti-LFA-1) 3.9 5.5  
C1498 B7-1 65.0 82.8  
EL4 8.3 8.8  
FBL 0 0  
Ly5.1 blasts 0 (15) 9.1 (5.0) 28.2 (7.5) 
Ly5.2 blasts 0 (5.1) 8.1 (8.2) 37.9 (7.5) 

Values represent mean % lysis as measured by 4-hour chromium release; standard deviation was <3% unless noted in parentheses.

*

Indicates effector to target ratio.

†

C1498 Lysis in the presence of 10 μg/mL of the indicated monoclonal antibody.

View Large
Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal