Percentage of Cells From NOD/SCID Mice With Leukemic Change as Detected by FISH or Cytogenetics (no. of colonies analyzed)
| Patient No. . | Cytogenetic Change . | % Positive . | % Positive . | % Positive . |
|---|---|---|---|---|
| . | . | in Blood . | in Marrow . | in Spleen . |
| Control | ||||
| 4 | del 11q23 | ND | 435-150 | ND |
| 7 | +13 | ND | 21 (5) | ND |
| 8 | inv 16 | 86 (10) | 100 (10) | ND |
| 9 | t(9; 11) | 60 | 71 | 60 |
| 10 | +8+8, t(9; 11) | 80 (5) | 85 (10) | ND |
| CD34+/Thy-1− | ||||
| 4 | del 11q23 | 67 | 100 | ND |
| 7 | +13 | 22 (5) | 40 | ND |
| 8 | inv 16 | ND | ND | 83 (10) |
| 9 | t(9; 11) | 67 | 73 | 60 |
| 10 | +8+8, t(9; 11) | 78 (5) | 99 (6) | ND |
| CD34− | ||||
| 7 | +13 | 0 | ND | ND |
| 9 | t(9; 11) | ND | 0 | 0 |
| 10 | +8+8, t(9; 11) | 96 (20) | 97 (20) | 99 (20) |
| Patient No. . | Cytogenetic Change . | % Positive . | % Positive . | % Positive . |
|---|---|---|---|---|
| . | . | in Blood . | in Marrow . | in Spleen . |
| Control | ||||
| 4 | del 11q23 | ND | 435-150 | ND |
| 7 | +13 | ND | 21 (5) | ND |
| 8 | inv 16 | 86 (10) | 100 (10) | ND |
| 9 | t(9; 11) | 60 | 71 | 60 |
| 10 | +8+8, t(9; 11) | 80 (5) | 85 (10) | ND |
| CD34+/Thy-1− | ||||
| 4 | del 11q23 | 67 | 100 | ND |
| 7 | +13 | 22 (5) | 40 | ND |
| 8 | inv 16 | ND | ND | 83 (10) |
| 9 | t(9; 11) | 67 | 73 | 60 |
| 10 | +8+8, t(9; 11) | 78 (5) | 99 (6) | ND |
| CD34− | ||||
| 7 | +13 | 0 | ND | ND |
| 9 | t(9; 11) | ND | 0 | 0 |
| 10 | +8+8, t(9; 11) | 96 (20) | 97 (20) | 99 (20) |
Where no number of colonies is indicated, the cells for cytogenetics were derived from CD45+ cells after short-term (≤3 days) suspension culture.