Clinical Characteristics of AML Patients and Cell Growth in Baseline Cultures
Patient No. . | FAB . | WBC × 109/L . | % Blasts in Blood . | Cytogenetic Change . | CFU*/105 . | CFU in SC wk 2† (per 105) . |
---|---|---|---|---|---|---|
1 | ND | 43 | 25 | +8 | 1,800 | 1,600 |
2 | M4 | 29 | 83 | −Y, t(8; 21) | 3 | 28 |
3 | M5 | 129 | 95 | +8, del 11q23 | ND | 15 |
4 | M5 | 47 | 23 | del 11q23 | 390 | 860 |
5 | M4 | 71 | 76 | +8 | 550 | 75 |
6 | M4 | 143 | 90 | Normal | 20 | 420 |
7 | M4 | 410 | 35 | +13 | 290 | 410 |
8 | M4e | 130 | 70 | inv 16 | 84 | 0 |
9 | M5 | 155 | 39 | t(9; 11) | 120 | 1,060 |
10 | M5 | 50 | 92 | +8, +8, t(9; 11) | 2,170 | 530 |
11 | M5 | 430 | 98 | ND | 14 | 14 |
12 | M4 | 103 | 42 | del 16q | 73 | 10 |
13 | M4e | 65 | 80 | inv 16 | 14 | 6 |
14 | M4e | 19 | 34 | inv 16 | 770 | 4 |
15 | M2 | 57 | 51 | +8, t(12; 22), del 20q | 2,920 | 740 |
Patient No. . | FAB . | WBC × 109/L . | % Blasts in Blood . | Cytogenetic Change . | CFU*/105 . | CFU in SC wk 2† (per 105) . |
---|---|---|---|---|---|---|
1 | ND | 43 | 25 | +8 | 1,800 | 1,600 |
2 | M4 | 29 | 83 | −Y, t(8; 21) | 3 | 28 |
3 | M5 | 129 | 95 | +8, del 11q23 | ND | 15 |
4 | M5 | 47 | 23 | del 11q23 | 390 | 860 |
5 | M4 | 71 | 76 | +8 | 550 | 75 |
6 | M4 | 143 | 90 | Normal | 20 | 420 |
7 | M4 | 410 | 35 | +13 | 290 | 410 |
8 | M4e | 130 | 70 | inv 16 | 84 | 0 |
9 | M5 | 155 | 39 | t(9; 11) | 120 | 1,060 |
10 | M5 | 50 | 92 | +8, +8, t(9; 11) | 2,170 | 530 |
11 | M5 | 430 | 98 | ND | 14 | 14 |
12 | M4 | 103 | 42 | del 16q | 73 | 10 |
13 | M4e | 65 | 80 | inv 16 | 14 | 6 |
14 | M4e | 19 | 34 | inv 16 | 770 | 4 |
15 | M2 | 57 | 51 | +8, t(12; 22), del 20q | 2,920 | 740 |
Abbreviations: ND, not determined; WBC, white blood cells.
CFU*, leukemic clusters (10-20 cells) plus colonies (>20 cells) counted after 14 days in methylcellulose culture per 105 cells plated.
SC wk 2†, CFU-blast in 2-week-old suspension cultures initiated with 105 cells. CFU numbers obtained after 2 weeks were doubled to correct for demi-depopulation at week 1.