Results of FISH Analysis Using 12p12 to p13 Probes in Nine Patients With Balanced 12p13 Rearrangements in Whom the YAC Signals Remained on the der(12)
| Probe order . | 15 . | 16 . | 17 . | 18 . | 193-150 . | 203-150 . | 21 . | 22 . | 23 . |
|---|---|---|---|---|---|---|---|---|---|
| . | t(12; 18) . | t(8; 12) . | t(1; 12) . | t(3; 12) . | t(12; 22) . | t(2; 12) . | t(12; 22) . | t(1; 12) . | inv(12) . |
| . | (p13; q12) . | (q1?1; p13) . | (p22; p13) . | (p21; p13),+12 . | (p13; q11) . | (p11; p13),+12 . | (p13; q13) . | (p32; p13) . | (p13.1q11) . |
| tel | → | clone 1 | clone 1 | ||||||
| D12S235 | der(12) | I | der(1) | der(22) | |||||
| → | |||||||||
| D12S237 | der(12) | der(12) | der(3) | der(22) | der(2) | der(22) | |||
| D12S134 | der(12) | der(1) | der(3) | der(22) | der(2) | der(22) | der(1) | 12p | |
| YAC961a6 | U | I | → | → | |||||
| der(12) | der(12) | ||||||||
| YAC771h4 | U → | I → | der(12) | der(12) | |||||
| D12S229 | der(12) | der(12) | der(12) | der(12) | der(22) | der(1) | 12p | ||
| HTY3049 c1-7 | der(12) | der(12) | der(12) | der(12) | der(22) | ||||
| → | der(1) | ||||||||
| → | 12p | ||||||||
| → | |||||||||
| D12S133 | der(12) | der(12) | der(12) | der(12)3-151 | der(12)3-152 | der(12) | der(12) | 12q | |
| YAC964 c10 | der(12) | der(12) | der(12) | der(12) | der(12) | der(12) | der(12) | der(12) | 12q |
| 15a4 | der(12) | der(12) | N | I | der(12) | U | der(12) | der(12) | 12q |
| 95h4 | der(12) | der(12) | N | I | der(12) | U | ∥ → | der(12) | 12q |
| TEL (exon 3) | der(12) | der(12) | der(12) | der(12) | der(12) | der(12) | der(22) | ||
| → | der(12) | 12q | |||||||
| der(12)ρ | |||||||||
| p27KIP2 | der(12) | der(12) | der(12) | der(12) | der(12) | der(12) | der(12) | der(12) | 12q |
| D12S142 | der(12) | der(12) | |||||||
| D12S119 | der(12) | der(12) | der(12) | der(12) | 12q | ||||
| GDI.D4 | der(12) | 12q | |||||||
| D12S54 | der(12) | ||||||||
| D12S140 | der(12) | ||||||||
| D12S20 | der(12) | der(12) | der(12) | 12q | |||||
| cen |
| Probe order . | 15 . | 16 . | 17 . | 18 . | 193-150 . | 203-150 . | 21 . | 22 . | 23 . |
|---|---|---|---|---|---|---|---|---|---|
| . | t(12; 18) . | t(8; 12) . | t(1; 12) . | t(3; 12) . | t(12; 22) . | t(2; 12) . | t(12; 22) . | t(1; 12) . | inv(12) . |
| . | (p13; q12) . | (q1?1; p13) . | (p22; p13) . | (p21; p13),+12 . | (p13; q11) . | (p11; p13),+12 . | (p13; q13) . | (p32; p13) . | (p13.1q11) . |
| tel | → | clone 1 | clone 1 | ||||||
| D12S235 | der(12) | I | der(1) | der(22) | |||||
| → | |||||||||
| D12S237 | der(12) | der(12) | der(3) | der(22) | der(2) | der(22) | |||
| D12S134 | der(12) | der(1) | der(3) | der(22) | der(2) | der(22) | der(1) | 12p | |
| YAC961a6 | U | I | → | → | |||||
| der(12) | der(12) | ||||||||
| YAC771h4 | U → | I → | der(12) | der(12) | |||||
| D12S229 | der(12) | der(12) | der(12) | der(12) | der(22) | der(1) | 12p | ||
| HTY3049 c1-7 | der(12) | der(12) | der(12) | der(12) | der(22) | ||||
| → | der(1) | ||||||||
| → | 12p | ||||||||
| → | |||||||||
| D12S133 | der(12) | der(12) | der(12) | der(12)3-151 | der(12)3-152 | der(12) | der(12) | 12q | |
| YAC964 c10 | der(12) | der(12) | der(12) | der(12) | der(12) | der(12) | der(12) | der(12) | 12q |
| 15a4 | der(12) | der(12) | N | I | der(12) | U | der(12) | der(12) | 12q |
| 95h4 | der(12) | der(12) | N | I | der(12) | U | ∥ → | der(12) | 12q |
| TEL (exon 3) | der(12) | der(12) | der(12) | der(12) | der(12) | der(12) | der(22) | ||
| → | der(12) | 12q | |||||||
| der(12)ρ | |||||||||
| p27KIP2 | der(12) | der(12) | der(12) | der(12) | der(12) | der(12) | der(12) | der(12) | 12q |
| D12S142 | der(12) | der(12) | |||||||
| D12S119 | der(12) | der(12) | der(12) | der(12) | 12q | ||||
| GDI.D4 | der(12) | 12q | |||||||
| D12S54 | der(12) | ||||||||
| D12S140 | der(12) | ||||||||
| D12S20 | der(12) | der(12) | der(12) | 12q | |||||
| cen |
Abbreviations: I, inadequate sample with no metaphase cells; U, unsuccessful hybridization; N, only normal cells seen.
These patients could have two clones.
Of 12 cells, six had signal on der(12) and six had signal on der(22).
In two of 14 cells, probe labeled der(2).
ρ Signal on der(12) and der(22) in eight of nine cells.
Only one metaphase seen; signal on normal 12 but not on der(12) or der(22).