Change in Study Parameter Mean Values After the Infusion of 1 Billion T Cells Enriched for HIV-Specific CTLs
| . | Baseline . | 1 wk . | 24 wk . |
|---|---|---|---|
| T-cell counts | |||
| Absolute CD4 count (/μL) | 273 ± 143 | 323 ± 197 | 297 ± 180 |
| Absolute CD8 count (/μL) | 1,402 ± 684 | 1,532 ± 859 | 1,558 ± 830 |
| CD4/CD8 ratio | 0.21 ± 0.12 | 0.23 ± 0.15 | 0.22 ± 0.16 |
| % Change in CD4 count | — | +10 ± 13 | +4 ± 71 |
| Viral burden | |||
| Cell-associated virus (IUPM) | 47 ± 66 | 23 ± 33 | 27 ± 31 |
| Log (IUPM) | 1.13 ± 0.92 | 0.080 ± 0.86 | 1.00 ± 0.85 |
| Plasma viremia (in Eq/mL ×10−3) | 44 ± 32 | 35 ± 28 | 35 ± 28 |
| Log (plasma HIV) | 4.36 ± 0.72 | 4.26 ± 0.71 | 4.27 ± 0.69 |
| HIV p24 Ag (only 1 subject detectable) | 171 | 152 | 51 |
| Miscellaneous | |||
| Weight (kg) | 88 ± 24 | 89 ± 24 | 91 ± 26 |
| β2 microglobulin | 2.5 ± 0.6 | 2.5 ± 0.6 | 2.5 ± 0.7 |
| . | Baseline . | 1 wk . | 24 wk . |
|---|---|---|---|
| T-cell counts | |||
| Absolute CD4 count (/μL) | 273 ± 143 | 323 ± 197 | 297 ± 180 |
| Absolute CD8 count (/μL) | 1,402 ± 684 | 1,532 ± 859 | 1,558 ± 830 |
| CD4/CD8 ratio | 0.21 ± 0.12 | 0.23 ± 0.15 | 0.22 ± 0.16 |
| % Change in CD4 count | — | +10 ± 13 | +4 ± 71 |
| Viral burden | |||
| Cell-associated virus (IUPM) | 47 ± 66 | 23 ± 33 | 27 ± 31 |
| Log (IUPM) | 1.13 ± 0.92 | 0.080 ± 0.86 | 1.00 ± 0.85 |
| Plasma viremia (in Eq/mL ×10−3) | 44 ± 32 | 35 ± 28 | 35 ± 28 |
| Log (plasma HIV) | 4.36 ± 0.72 | 4.26 ± 0.71 | 4.27 ± 0.69 |
| HIV p24 Ag (only 1 subject detectable) | 171 | 152 | 51 |
| Miscellaneous | |||
| Weight (kg) | 88 ± 24 | 89 ± 24 | 91 ± 26 |
| β2 microglobulin | 2.5 ± 0.6 | 2.5 ± 0.6 | 2.5 ± 0.7 |
None of the changes were statistically significant.
The values given are the cross-sectional means and standard deviations for each time point. Data were available for all subjects at each time point.