Table 3.

Results of Multipoint Linkage Analysis Between Type III PS Deficiency and the PROS1 Gene in Family PS10

Intermarker ThetasPS10
log (like)Lod Scores
Loci: 123 
0.5 0.00001 −12.113 0 
0.01 0.00001 −13.337 −1.224 
0.005 0.00001 −13.639 −1.526 
0.0025 0.00001 −13.940 −1.827 
0.0016 0.00001 −14.134 −2.021 
0 0.00001 −18.996 −6.883 
Loci: 213 
0 0.00001 −18.996 −6.883 
0.000005 0.000005 −17.112 −4.999 
0.00001 0 −16.814 −4.701 
Loci: 231 
0.00001 0.5 −12.113 0 
0.00001 0.01 −13.337 −1.224 
0.00001 0.005 −13.639 −1.526 
0.00001 0.0025 −13.940 −1.827 
0.00001 0.0016 −14.133 −2.020 
0.00001 0 −∞ −∞ 
Intermarker ThetasPS10
log (like)Lod Scores
Loci: 123 
0.5 0.00001 −12.113 0 
0.01 0.00001 −13.337 −1.224 
0.005 0.00001 −13.639 −1.526 
0.0025 0.00001 −13.940 −1.827 
0.0016 0.00001 −14.134 −2.021 
0 0.00001 −18.996 −6.883 
Loci: 213 
0 0.00001 −18.996 −6.883 
0.000005 0.000005 −17.112 −4.999 
0.00001 0 −16.814 −4.701 
Loci: 231 
0.00001 0.5 −12.113 0 
0.00001 0.01 −13.337 −1.224 
0.00001 0.005 −13.639 −1.526 
0.00001 0.0025 −13.940 −1.827 
0.00001 0.0016 −14.133 −2.020 
0.00001 0 −∞ −∞ 

The position of the disease locus (numbered as 1) with respect to the fixed map of the two PROS1 gene markers, S460P (locus 2) and P626 A/G (locus 3), is shown at the top of the corresponding column indicating the recombination fractions between loci (intermarker thetas).

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