Distribution of Alleles for the S460P Polymorphism (PS Heerlen) in Exon 13 of the PROS1 Gene in 45 Patients With Different Types of PS Deficiency and in 150 Healthy Controls
| Alleles S/P . | Controls . | PS Deficiency . | |||
|---|---|---|---|---|---|
| . | . | Type I . | Type III . | Type I/III . | Total . |
| S | 299 (99.66) | 25 (96.2) | 37 (80.4) | 17 (94.4) | 79 (87.8) |
| P | 1 (0.33) | 1 (3.8) | 9 (19.6) | 1 (5.6) | 11 (12.2) |
| Total | 300 (100) | 26 (100) | 46 (100) | 18 (100) | 90 (100) |
| χ2 test | NS | P < .001 | NS | P < .001 | |
| Alleles S/P . | Controls . | PS Deficiency . | |||
|---|---|---|---|---|---|
| . | . | Type I . | Type III . | Type I/III . | Total . |
| S | 299 (99.66) | 25 (96.2) | 37 (80.4) | 17 (94.4) | 79 (87.8) |
| P | 1 (0.33) | 1 (3.8) | 9 (19.6) | 1 (5.6) | 11 (12.2) |
| Total | 300 (100) | 26 (100) | 46 (100) | 18 (100) | 90 (100) |
| χ2 test | NS | P < .001 | NS | P < .001 | |
Values are the number of chromosomes with percentages in parentheses.
Abbreviations: S and P are serine or proline at codon 460 (TCC/CCC); NS, not significant.