Enlarged Number and Size of Granulomas Induced by Corynebacterium parvum in CD44−/− Mice
| Genotype . | Number . | Size . |
|---|---|---|
| CD44+/− | 17.8 ± 9.7 | 25.2 ± 1.5 |
| CD44−/− | 30.5 ± 9.0 | 36.5 ± 3.7 |
| (P < .03) | (P < .001) |
| Genotype . | Number . | Size . |
|---|---|---|
| CD44+/− | 17.8 ± 9.7 | 25.2 ± 1.5 |
| CD44−/− | 30.5 ± 9.0 | 36.5 ± 3.7 |
| (P < .03) | (P < .001) |
CD44 influences the formation of C parvum-induced granulomas. CD44-deficient and wild-type mice (n = 6) were injected with 7.5 mg/kg of heat-killed C parvum. Mice were sacrificed 14 days after injection, and liver sections were analyzed for granuloma formation. Significance was calculated by Student's t-test.