Anti-D Treatment in ITP: Review of Published Studies
| Study . | Patients . | Mean Platelet Increase (×1,000/μL) . | Mean Hemoglobin Decrease (g/dL) . | Comments . | ||
|---|---|---|---|---|---|---|
| . | . | . | . | . | . | . |
| Children | 1 | 11 | No change | |||
| (1) Acute ITP, HIV− | ||||||
| Panzer21 (1986) | ||||||
| Becker22 (1986) | 5 | 26 | Stable | Platelet increase at day 10 (figures) | ||
| Smith23 (1989) | 1 | 110 | NR | |||
| Blanchette24 (1994) | 38 | 239 | 1.52 | Data provided by author, patients treated at diagnosis | ||
| Current study | 47 | 108 | 0.6 | Platelet and hemoglobin changes at day 7, 2 patients treated at diagnosis | ||
| (2) Chronic ITP, HIV− | 1 | 22 | No change | |||
| Panzer21 (1986) | ||||||
| Becker22 (1986) | 10 | 118 | Stable | Platelet increase at day 10 (figures) | ||
| Andrew25 (1991) | 25 | 200 | 1.4 | Platelet increase at day 7 (figure) | ||
| Borgna-Pignatti26 (1994) | 7 | 119 | 1.6 | Intramuscular administration, max/min counts | ||
| Current study | 61 | 111 | 1.0 | Platelet and hemoglobin changes at day 7 | ||
| (3) Acute/chronic, HIV+ | ||||||
| No previous study | ||||||
| Current study | 20 | 65 | 0.7 | Platelet and hemoglobin changes at day 7 | ||
| Adults | ||||||
| (1) Acute ITP, HIV− | ||||||
| No previous study | ||||||
| Current study | 10 | 33 | 0.9 | Platelet and hemoglobin changes at day 7 | ||
| (2) Chronic ITP, HIV− | ||||||
| Salama19 (1984/1986) | 6 | 52 | 0.3 | Peak values | ||
| Salama20 (1986) | 13 | 71 | 0.7 | Peak values | ||
| Baglin35 (1986) | 3 | 115 | NR | |||
| Panzer21 (1986) | 3 | 71 | NR | |||
| Boughton27 (1988) | 7 | 107 | 0.9 | |||
| Smith28 (1990) | 4 | 94 | NR | |||
| Gringeri30 (1991) | 27 | 76 | 1.2 | Median values | ||
| Rodeghiero31 (1992) | 8 | 118 | 2.4 | |||
| Current study | 42 | 49 | 1.0 | Platelet and hemoglobin changes at day 7 | ||
| (3) Acute ITP, HIV+ | ||||||
| Rossi32 (1987) | 9 | 132 | 1.7 | Peak post-Tx platelet count, most patients had no prior Tx | ||
| Current study | 18 | 41 | 0.7 | Platelet and hemoglobin changes at day 7 | ||
| (4) Chronic ITP, HIV+ | ||||||
| Rossi32 (1987) | 4 | 107 | 1.0 | Peak Post-Tx platelet count, patients had prior Tx | ||
| Oskenhendler33 (1988) | 14 | 44 | 0.4-2.2 | Platelet increase at days 3-12, patients had prior Tx | ||
| Gringeri30 (1991) | 24 | 92 | 1.2 | Median values (IV induction), no prior Tx | ||
| Current study | 67 | 47 | 1.0 | Platelet and hemoglobin changes at day 7 | ||
| Splenectomized patients | Dose | Preparation | Administration | |||
| Baglin35 (1986) | 2 | 31 | NR | 100 μg × 5 | Anti-Rh(D) | IV |
| Salama20 (1986) | 4 | 19 | 1.7 | 300-3,600 μg | Anti-Rh(D) | IV |
| Cardo36 (1991) | 2 | 42 | NR | 1800 μg × 3 | Rhogam | SC |
| Current study | 11 | 27 | 1.1 | 100-200 μg/kg | WinRho SD | IV/SC |
| Study . | Patients . | Mean Platelet Increase (×1,000/μL) . | Mean Hemoglobin Decrease (g/dL) . | Comments . | ||
|---|---|---|---|---|---|---|
| . | . | . | . | . | . | . |
| Children | 1 | 11 | No change | |||
| (1) Acute ITP, HIV− | ||||||
| Panzer21 (1986) | ||||||
| Becker22 (1986) | 5 | 26 | Stable | Platelet increase at day 10 (figures) | ||
| Smith23 (1989) | 1 | 110 | NR | |||
| Blanchette24 (1994) | 38 | 239 | 1.52 | Data provided by author, patients treated at diagnosis | ||
| Current study | 47 | 108 | 0.6 | Platelet and hemoglobin changes at day 7, 2 patients treated at diagnosis | ||
| (2) Chronic ITP, HIV− | 1 | 22 | No change | |||
| Panzer21 (1986) | ||||||
| Becker22 (1986) | 10 | 118 | Stable | Platelet increase at day 10 (figures) | ||
| Andrew25 (1991) | 25 | 200 | 1.4 | Platelet increase at day 7 (figure) | ||
| Borgna-Pignatti26 (1994) | 7 | 119 | 1.6 | Intramuscular administration, max/min counts | ||
| Current study | 61 | 111 | 1.0 | Platelet and hemoglobin changes at day 7 | ||
| (3) Acute/chronic, HIV+ | ||||||
| No previous study | ||||||
| Current study | 20 | 65 | 0.7 | Platelet and hemoglobin changes at day 7 | ||
| Adults | ||||||
| (1) Acute ITP, HIV− | ||||||
| No previous study | ||||||
| Current study | 10 | 33 | 0.9 | Platelet and hemoglobin changes at day 7 | ||
| (2) Chronic ITP, HIV− | ||||||
| Salama19 (1984/1986) | 6 | 52 | 0.3 | Peak values | ||
| Salama20 (1986) | 13 | 71 | 0.7 | Peak values | ||
| Baglin35 (1986) | 3 | 115 | NR | |||
| Panzer21 (1986) | 3 | 71 | NR | |||
| Boughton27 (1988) | 7 | 107 | 0.9 | |||
| Smith28 (1990) | 4 | 94 | NR | |||
| Gringeri30 (1991) | 27 | 76 | 1.2 | Median values | ||
| Rodeghiero31 (1992) | 8 | 118 | 2.4 | |||
| Current study | 42 | 49 | 1.0 | Platelet and hemoglobin changes at day 7 | ||
| (3) Acute ITP, HIV+ | ||||||
| Rossi32 (1987) | 9 | 132 | 1.7 | Peak post-Tx platelet count, most patients had no prior Tx | ||
| Current study | 18 | 41 | 0.7 | Platelet and hemoglobin changes at day 7 | ||
| (4) Chronic ITP, HIV+ | ||||||
| Rossi32 (1987) | 4 | 107 | 1.0 | Peak Post-Tx platelet count, patients had prior Tx | ||
| Oskenhendler33 (1988) | 14 | 44 | 0.4-2.2 | Platelet increase at days 3-12, patients had prior Tx | ||
| Gringeri30 (1991) | 24 | 92 | 1.2 | Median values (IV induction), no prior Tx | ||
| Current study | 67 | 47 | 1.0 | Platelet and hemoglobin changes at day 7 | ||
| Splenectomized patients | Dose | Preparation | Administration | |||
| Baglin35 (1986) | 2 | 31 | NR | 100 μg × 5 | Anti-Rh(D) | IV |
| Salama20 (1986) | 4 | 19 | 1.7 | 300-3,600 μg | Anti-Rh(D) | IV |
| Cardo36 (1991) | 2 | 42 | NR | 1800 μg × 3 | Rhogam | SC |
| Current study | 11 | 27 | 1.1 | 100-200 μg/kg | WinRho SD | IV/SC |
Platelet and hemoglobin changes were calculated as the difference between the pretreatment and the peak posttreatment counts; mean values are shown.
Abbreviations: Figure, data obtained from graphs; Tx, treatment; NR, not reported.