Duration of Effect of Anti-D Treatment: Length of Platelet Response After the Initial Infusion
| . | . | Response Duration (d) . | |||||
|---|---|---|---|---|---|---|---|
| . | . | <7 . | >7 . | >14 . | >21 . | >28 . | >42 . |
| All responding patients | (N = 189) | 4 | 98% (185) | 75% (141) | 50% (94) | 37% (69) | 15% (29) |
| Responding patients with platelet increase >50 | (N = 120) | 100% (120) | 78% (94)4-150 | 57% (69)4-150 | 43% (52)4-150 | 17% (20) | |
| Responding patients with platelet increase 20-50 | (N = 69) | 1 | 98% (68) | 52% (36)4-150 | 30% (21)4-150 | 20% (14)4-150 | 10% (7) |
| HIV− children | (N = 86) | 3 | 97% (83) | 73% (63) | 45% (39) | 35% (30) | 15% (13) |
| HIV+ children | (N = 14) | 100% (14) | 93% (13) | 71% (10) | 57% (8) | 7% (1) | |
| HIV− adults | (N = 36) | 1 | 97% (35) | 75% (27) | 53% (19) | 36% (13) | 19% (7) |
| HIV+ adults | (N = 53) | 100% (53) | 72% (38) | 51% (27) | 36% (19) | 15% (8) | |
| . | . | Response Duration (d) . | |||||
|---|---|---|---|---|---|---|---|
| . | . | <7 . | >7 . | >14 . | >21 . | >28 . | >42 . |
| All responding patients | (N = 189) | 4 | 98% (185) | 75% (141) | 50% (94) | 37% (69) | 15% (29) |
| Responding patients with platelet increase >50 | (N = 120) | 100% (120) | 78% (94)4-150 | 57% (69)4-150 | 43% (52)4-150 | 17% (20) | |
| Responding patients with platelet increase 20-50 | (N = 69) | 1 | 98% (68) | 52% (36)4-150 | 30% (21)4-150 | 20% (14)4-150 | 10% (7) |
| HIV− children | (N = 86) | 3 | 97% (83) | 73% (63) | 45% (39) | 35% (30) | 15% (13) |
| HIV+ children | (N = 14) | 100% (14) | 93% (13) | 71% (10) | 57% (8) | 7% (1) | |
| HIV− adults | (N = 36) | 1 | 97% (35) | 75% (27) | 53% (19) | 36% (13) | 19% (7) |
| HIV+ adults | (N = 53) | 100% (53) | 72% (38) | 51% (27) | 36% (19) | 15% (8) | |
The values shown are percentages with the number of patients (N) in parentheses. Response was defined as a platelet increase ≥20. Duration of the anti-D effect was evaluated as follows: time for the platelet count to return to less than 20 (if the pretreatment count was <20) or to return to baseline (if the pretreatment count was >20) or time interval to the next infusion, whichever occurred first. Age and HIV status did not influence the response duration.
The platelet increase had a significant effect on the duration of response after anti-D (P < .01).