Preparation of Anti-D (WinRho or WinRho SD): Effect on Platelet Response and Hemoglobin Change
| Preparation . | Patients (N) . | <18 yr, HIV− . | Dose3-150 (mean) . | Mean Platelet Increase (SD) (×1,000/μL) . | Mean Hemoglobin Decrease (g/dL) (SD) . | |
|---|---|---|---|---|---|---|
| . | . | N . | % . | . | . | . |
| WinRho | 139 | 57 | 41 | 31.0 | 72 (99.9) | 0.9 (1.0) |
| WinRho SD | 92 | 38 | 41 | 42.4 | 93 (100.6) | 0.8 (1.1) |
| P = .12 | P = NS | |||||
| Preparation . | Patients (N) . | <18 yr, HIV− . | Dose3-150 (mean) . | Mean Platelet Increase (SD) (×1,000/μL) . | Mean Hemoglobin Decrease (g/dL) (SD) . | |
|---|---|---|---|---|---|---|
| . | . | N . | % . | . | . | . |
| WinRho | 139 | 57 | 41 | 31.0 | 72 (99.9) | 0.9 (1.0) |
| WinRho SD | 92 | 38 | 41 | 42.4 | 93 (100.6) | 0.8 (1.1) |
| P = .12 | P = NS | |||||
All patients were analyzed according to the anti-D preparation they received for their initial treatment. The distribution of patients with the best responses (HIV− children) was similar in the two groups. Platelet increase and hemoglobin decrease were calculated as the difference between the pretreatment and the day 7 posttreatment values.
There was a significant difference in the dose of anti-D between the two groups (dose in micrograms per kilogram).