Response to Initial Anti-D Treatment: Interaction of Age and HIV Status — Distribution of Responses
| . | All Patients (N = 261) . | Age <18 yr . | Age >18 yr . | ||||
|---|---|---|---|---|---|---|---|
| . | . | All Children (N = 124) . | HIV− (N = 104) . | HIV+ (N = 20) . | All Adults (N = 137) . | HIV− (N = 52) . | HIV+ (N = 85) . |
| Platelet increases | |||||||
| <20 | 27% (72) | 19% (24) | 17% (18) | 30% (6) | 35% (48) | 31% (16) | 38% (32) |
| 20-50 | 27% (70) | 22% (27) | 21% (22) | 25% (5) | 31% (43) | 37% (19) | 28% (24) |
| 51-99 | 20% (52) | 18% (22) | 19% (20) | 10% (2) | 22% (30) | 21% (11) | 22% (19) |
| >100 | 26% (67) | 41% (51) | 42% (44) | 35% (7) | 12% (16) | 12% (6) | 12% (10) |
| Platelet increase ≥20 | 72% (189) | 81% (100) | 83% (86) | 70% (14) | 65% (89) | 69% (36) | 62% (53) |
| Platelet increase >50 | 45% (119) | 59% (73) | 62% (64) | 45% (9) | 34% (46) | 33% (17) | 34% (29) |
| Posttreatment platelet count | |||||||
| 2× baseline and >50 | 54% (140) | 66% (82) | 70% (72) | 50% (10) | 42% (58) | 40% (21) | 44% (37) |
| . | All Patients (N = 261) . | Age <18 yr . | Age >18 yr . | ||||
|---|---|---|---|---|---|---|---|
| . | . | All Children (N = 124) . | HIV− (N = 104) . | HIV+ (N = 20) . | All Adults (N = 137) . | HIV− (N = 52) . | HIV+ (N = 85) . |
| Platelet increases | |||||||
| <20 | 27% (72) | 19% (24) | 17% (18) | 30% (6) | 35% (48) | 31% (16) | 38% (32) |
| 20-50 | 27% (70) | 22% (27) | 21% (22) | 25% (5) | 31% (43) | 37% (19) | 28% (24) |
| 51-99 | 20% (52) | 18% (22) | 19% (20) | 10% (2) | 22% (30) | 21% (11) | 22% (19) |
| >100 | 26% (67) | 41% (51) | 42% (44) | 35% (7) | 12% (16) | 12% (6) | 12% (10) |
| Platelet increase ≥20 | 72% (189) | 81% (100) | 83% (86) | 70% (14) | 65% (89) | 69% (36) | 62% (53) |
| Platelet increase >50 | 45% (119) | 59% (73) | 62% (64) | 45% (9) | 34% (46) | 33% (17) | 34% (29) |
| Posttreatment platelet count | |||||||
| 2× baseline and >50 | 54% (140) | 66% (82) | 70% (72) | 50% (10) | 42% (58) | 40% (21) | 44% (37) |
The values shown are percentages with the number of patients (N) in parentheses. Platelet increase was calculated as the difference between the pretreatment and the day 7 posttreatment platelet count. Response was defined as a platelet increase ≥20. There was a significant difference (P = .005) in the mean platelet increases between HIV− and HIV+ children. No difference between the two pediatric groups was seen for platelet increases greater than 50. There was no difference in the mean platelet increases and responses between HIV− and HIV+ adults. Patients who achieved a certain posttreatment count (doubling of the pretreatment value and >50) are presented.