Uneven Distribution of IMPs in the Total Protein 4.1 Deficiency
| No. of IMPs . | Frequency (%) . | |
|---|---|---|
| (per 33 nm2 ) . | Normal . | Protein 4.1 (−) Madrid . |
| . | (n = 5) . | (n = 1) . |
| 0-3 | 2.4 ± 1.0 | 11.7 ± 2.54-150 |
| 4-5 | 18.1 ± 3.0 | 27.0 ± 3.24-150 |
| 6-11 | 79.5 ± 9.8 | 61.3 ± 7.64-150 |
| No. of IMPs . | Frequency (%) . | |
|---|---|---|
| (per 33 nm2 ) . | Normal . | Protein 4.1 (−) Madrid . |
| . | (n = 5) . | (n = 1) . |
| 0-3 | 2.4 ± 1.0 | 11.7 ± 2.54-150 |
| 4-5 | 18.1 ± 3.0 | 27.0 ± 3.24-150 |
| 6-11 | 79.5 ± 9.8 | 61.3 ± 7.64-150 |
After EM using the FF method was performed, the number of IMPs (per each 33 nm2 ) at the inner (so-called “P”) face was counted to determine the distribution of IMPs on the membrane faces in 10 microphotographs from each normal subject (n = 5, obs 45,000) and the 4.1 (−) Madrid case (n = 1, obs 9,000). The relative frequency in each category was expressed in percentages.
Statistical significance in P < .05.