Baseline and Two-Year Change in Laboratory Determinations by Two-Year HbF Quartile
| Variable . | HU Total . | HU Quartile 1 (n = 34) . | HU Quartile 2 (n = 38) . | HU Quartile 3 (n = 36) . | HU Quartile 4 (n = 35) . | Placebo . |
|---|---|---|---|---|---|---|
| . | (n = 143) . | . | . | . | . | (n = 135) . |
| CAR haplotype (%) | 41 | 45 | 28 | 20 | ||
| HbF (%) | 5.1 (3.5) | 5.4 (3.2) | 3.6 (2.4) | 5.1 (4.0) | 6.4 (3.8) | 5.2 (3.6) |
| Δ2-yr | 3.6 (5.4) | −1.5 (1.1) | 0.6 (0.6) | 3.7 (1.4) | 11.7 (3.8) | −0.4 (2.0) |
| F cells (%) | 33.0 (16.7) | 33.9 (15.4) | 25.9 (13.2) | 33.5 (19.9) | 39.6 (15.6) | 32.8 (16.9) |
| Δ2-yr | 15.2 (17.3) | −1.1 (9.3) | 8.1 (9.2) | 17.7 (11.7) | 36.2 (12.0) | 2.3 (7.1) |
| F reticulocytes | 14.7 (8.0) | 15.6 (9.1) | 13.1 (7.0) | 13.1 (7.4) | 17.2 (7.9) | 14.7 (7.6) |
| Δ2-yr | 2.7 (5.7) | −0.6 (2.5) | 0.4 (2.6) | 3.0 (3.9) | 8.2 (7.8) | −0.1 (2.4) |
| MCV (fl) | 93.6 (9.3) | 94.0 (8.7) | 92.8 (11.2) | 92.3 (9.7) | 95.3 (7.1) | 93.3 (8.6) |
| Δ2-yr | 9.7 (11.2) | −1.4 (5.2) | 4.0 (7.1) | 13.3 (6.7) | 22.8 (7.0) | −0.4 (4.8) |
| Neutrophils4-150 | 6.8 (2.3) | 5.9 (1.8) | 6.9 (2.4) | 6.7 (1.8) | 7.7 (2.6) | 6.7 (2.3) |
| Δ2-yr | −1.9 (2.4) | −0.3 (1.7) | −1.0 (2.0) | −2.2 (1.5) | −4.1 (2.3) | −0.4 (2.2) |
| Reticulocytes4-151 | 327 (100) | 316 (120) | 322 (96) | 306 (104) | 367 (64) | 324 (94) |
| Δ2-yr | −97 (107) | −37 (59) | −37 (85) | −95 (81) | −223 (73) | −21 (72) |
| Variable . | HU Total . | HU Quartile 1 (n = 34) . | HU Quartile 2 (n = 38) . | HU Quartile 3 (n = 36) . | HU Quartile 4 (n = 35) . | Placebo . |
|---|---|---|---|---|---|---|
| . | (n = 143) . | . | . | . | . | (n = 135) . |
| CAR haplotype (%) | 41 | 45 | 28 | 20 | ||
| HbF (%) | 5.1 (3.5) | 5.4 (3.2) | 3.6 (2.4) | 5.1 (4.0) | 6.4 (3.8) | 5.2 (3.6) |
| Δ2-yr | 3.6 (5.4) | −1.5 (1.1) | 0.6 (0.6) | 3.7 (1.4) | 11.7 (3.8) | −0.4 (2.0) |
| F cells (%) | 33.0 (16.7) | 33.9 (15.4) | 25.9 (13.2) | 33.5 (19.9) | 39.6 (15.6) | 32.8 (16.9) |
| Δ2-yr | 15.2 (17.3) | −1.1 (9.3) | 8.1 (9.2) | 17.7 (11.7) | 36.2 (12.0) | 2.3 (7.1) |
| F reticulocytes | 14.7 (8.0) | 15.6 (9.1) | 13.1 (7.0) | 13.1 (7.4) | 17.2 (7.9) | 14.7 (7.6) |
| Δ2-yr | 2.7 (5.7) | −0.6 (2.5) | 0.4 (2.6) | 3.0 (3.9) | 8.2 (7.8) | −0.1 (2.4) |
| MCV (fl) | 93.6 (9.3) | 94.0 (8.7) | 92.8 (11.2) | 92.3 (9.7) | 95.3 (7.1) | 93.3 (8.6) |
| Δ2-yr | 9.7 (11.2) | −1.4 (5.2) | 4.0 (7.1) | 13.3 (6.7) | 22.8 (7.0) | −0.4 (4.8) |
| Neutrophils4-150 | 6.8 (2.3) | 5.9 (1.8) | 6.9 (2.4) | 6.7 (1.8) | 7.7 (2.6) | 6.7 (2.3) |
| Δ2-yr | −1.9 (2.4) | −0.3 (1.7) | −1.0 (2.0) | −2.2 (1.5) | −4.1 (2.3) | −0.4 (2.2) |
| Reticulocytes4-151 | 327 (100) | 316 (120) | 322 (96) | 306 (104) | 367 (64) | 324 (94) |
| Δ2-yr | −97 (107) | −37 (59) | −37 (85) | −95 (81) | −223 (73) | −21 (72) |