Collagen-Induced Platelet Prothrombinase in Thrombasthenia
| Stirring (− or +) . | Total . | Agonist Specific* . | Total . | Agonist Specific* . |
|---|---|---|---|---|
| . | − . | − . | + . | + . |
| . | . | |||
| . | . | . | . | . |
| . | (pmol thrombin/108 platelets)† . | |||
| . | . | . | . | . |
| Controls (x̄ ± SE) | 999 ± 99 | 183 ± 168 | 2,373 ± 129 | 1,065 ± 150 |
| Thrombasthenics | ||||
| LW | 1,167 | 696 | 2,169 | 1,080 |
| MC | 1,602 | 375 | 3,315 | 1,455 |
| CG | 2,049 | 1,095 | 3,510 | 1,767 |
| AE | 2,847 | 1,539 | 3,666 | 1,704 |
| LM | 1,257 | 933 | 2,235 | 879 |
| x̄ ± SE | 1,784 ± 308‡ | 928 ± 195ρ | 2,979 ± 322 | 1,377 ± 173 |
| Stirring (− or +) . | Total . | Agonist Specific* . | Total . | Agonist Specific* . |
|---|---|---|---|---|
| . | − . | − . | + . | + . |
| . | . | |||
| . | . | . | . | . |
| . | (pmol thrombin/108 platelets)† . | |||
| . | . | . | . | . |
| Controls (x̄ ± SE) | 999 ± 99 | 183 ± 168 | 2,373 ± 129 | 1,065 ± 150 |
| Thrombasthenics | ||||
| LW | 1,167 | 696 | 2,169 | 1,080 |
| MC | 1,602 | 375 | 3,315 | 1,455 |
| CG | 2,049 | 1,095 | 3,510 | 1,767 |
| AE | 2,847 | 1,539 | 3,666 | 1,704 |
| LM | 1,257 | 933 | 2,235 | 879 |
| x̄ ± SE | 1,784 ± 308‡ | 928 ± 195ρ | 2,979 ± 322 | 1,377 ± 173 |
Agonist-specific values obtained by subtracting the value obtained for the saline-treated sample (constituitive) from the total activity.
pmol thrombin formed per 108 platelets during a 3-minute incubation period in the prothrombinase assay (see Materials and Methods).
P value v controls: ‡ <.05, ρ <.01.