Characteristics of CNS Disease in 16 Patients at Time of Their First Overt Clinical Neurological Manifestations
| Age (mo) . | Primary (I) or Secondary Onset (II) . | Clinical Symptoms . | Radiological Symptoms . |
|---|---|---|---|
| 1 | I | Coma | MRI: White matter abnormalities |
| Seizures | CT Scan: Calcifications | ||
| Brain stem symptoms | Abnormal contrast enhancement | ||
| 1.5 | I | Brain stem symptoms | ND |
| 2 | I | Coma | CT Scan: Abnormal contrast enhancement |
| Subdural space dilatation | |||
| 3 | I | Coma | CT Scan: Severe necrotic areas |
| Seizures | White matter abnormalities | ||
| Brain stem symptoms | Subdural space dilatation | ||
| 4 | I | Seizures | CT Scan: Severe atrophy |
| Brain stem symptoms | |||
| 17 | I | Coma | CT Scan: Severe atrophy |
| Seizures | |||
| 19 | I | Coma | CT Scan: Necrotic areas |
| Seizures | |||
| Hemiplegia | |||
| 46 | I | Ataxia | CT Scan: White matter abnormalities |
| Somnolence | |||
| Meningism | |||
| 58 | I | Ataxia | CT Scan: White matter abnormalities |
| 6 | II | Coma | |
| Tetraparesis | |||
| Brain stem symptoms | ND | ||
| Developmental delay | |||
| 7 | II | Developmental delay | CT Scan: Calcifications |
| 8 | II | Seizures | CT Scan: Severe atrophy |
| 13 | II | Developmental delay | MRI: White matter abnormalities |
| CT Scan: Calcifications | |||
| Abnormal contrast enhancement | |||
| 13 | II | Developmental delay | MRI: White matter abnormalities |
| Coma | CT Scan: Normal | ||
| Seizures | |||
| Tetraparesis | |||
| 14 | II | Coma | MRI: White matter abnormalities |
| 57 | II | Ataxia | MRI: Necrotic areas |
| White matter abnormalities |
| Age (mo) . | Primary (I) or Secondary Onset (II) . | Clinical Symptoms . | Radiological Symptoms . |
|---|---|---|---|
| 1 | I | Coma | MRI: White matter abnormalities |
| Seizures | CT Scan: Calcifications | ||
| Brain stem symptoms | Abnormal contrast enhancement | ||
| 1.5 | I | Brain stem symptoms | ND |
| 2 | I | Coma | CT Scan: Abnormal contrast enhancement |
| Subdural space dilatation | |||
| 3 | I | Coma | CT Scan: Severe necrotic areas |
| Seizures | White matter abnormalities | ||
| Brain stem symptoms | Subdural space dilatation | ||
| 4 | I | Seizures | CT Scan: Severe atrophy |
| Brain stem symptoms | |||
| 17 | I | Coma | CT Scan: Severe atrophy |
| Seizures | |||
| 19 | I | Coma | CT Scan: Necrotic areas |
| Seizures | |||
| Hemiplegia | |||
| 46 | I | Ataxia | CT Scan: White matter abnormalities |
| Somnolence | |||
| Meningism | |||
| 58 | I | Ataxia | CT Scan: White matter abnormalities |
| 6 | II | Coma | |
| Tetraparesis | |||
| Brain stem symptoms | ND | ||
| Developmental delay | |||
| 7 | II | Developmental delay | CT Scan: Calcifications |
| 8 | II | Seizures | CT Scan: Severe atrophy |
| 13 | II | Developmental delay | MRI: White matter abnormalities |
| CT Scan: Calcifications | |||
| Abnormal contrast enhancement | |||
| 13 | II | Developmental delay | MRI: White matter abnormalities |
| Coma | CT Scan: Normal | ||
| Seizures | |||
| Tetraparesis | |||
| 14 | II | Coma | MRI: White matter abnormalities |
| 57 | II | Ataxia | MRI: Necrotic areas |
| White matter abnormalities |
Abbreviations: MRI, magnetic resonance imaging; CT Scan, computed tomographic scans; ND, not determined.