Fraction of Erythroid Cells Recovered From Epo-Stimulated Cultures of Normal and MDS Marrow
| Growth Factor Added . | NBM . | RA . | RAEB . | RAEB-t . | CMML . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | 1 . | 2 . | 3 . | 1* . | 2* . | 6* . | 7* . | 8* . | 10* . | 11* . | 13* . | 14* . | 15* . | 17* . | 21* . |
| — | 1.2 | 0.7 | 0.1 | 1.1 | 0.1 | 0 | NA | 0.2 | 0.2 | 0 | 0.4 | 0.4 | 0.5 | 0.1 | 0.1 |
| Epo | 2.7 | 2.5 | 0.9 | 0.6 | 0.2 | 0.2 | 0 | 0.4 | 0.1 | 0.5 | 0.9 | 0.4 | 0.6 | 0 | 0.7 |
| Epo + IL-3 | 5.3 | 8.5 | 1.6 | 0.5 | 0.1 | 0 | 0.1 | 0.2 | 0.2 | 0 | 0.9 | 0.4 | 0.2 | 0.1 | 0.4 |
| Epo + SCF | 9.6 | 3.0 | 2.0 | 0.7 | 0.1 | 0.5 | 0.1 | 0.1 | 0.1 | 0 | 1.1 | 0.3 | 0.2 | 0 | 0.2 |
| IL-3 | 1.2 | 0.8 | 0.8 | 0.7 | 0.1 | 0.8 | 0 | 0.1 | 0 | 0 | 0.2 | 0.1 | 0.5 | 0 | 0.5 |
| SCF | 1.2 | 0.6 | 0.7 | 0.5 | 0.1 | 0.3 | NA | 0.1 | 0.1 | 0 | 0.5 | 0.1 | 0.5 | 0 | 0.7 |
| Growth Factor Added . | NBM . | RA . | RAEB . | RAEB-t . | CMML . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | 1 . | 2 . | 3 . | 1* . | 2* . | 6* . | 7* . | 8* . | 10* . | 11* . | 13* . | 14* . | 15* . | 17* . | 21* . |
| — | 1.2 | 0.7 | 0.1 | 1.1 | 0.1 | 0 | NA | 0.2 | 0.2 | 0 | 0.4 | 0.4 | 0.5 | 0.1 | 0.1 |
| Epo | 2.7 | 2.5 | 0.9 | 0.6 | 0.2 | 0.2 | 0 | 0.4 | 0.1 | 0.5 | 0.9 | 0.4 | 0.6 | 0 | 0.7 |
| Epo + IL-3 | 5.3 | 8.5 | 1.6 | 0.5 | 0.1 | 0 | 0.1 | 0.2 | 0.2 | 0 | 0.9 | 0.4 | 0.2 | 0.1 | 0.4 |
| Epo + SCF | 9.6 | 3.0 | 2.0 | 0.7 | 0.1 | 0.5 | 0.1 | 0.1 | 0.1 | 0 | 1.1 | 0.3 | 0.2 | 0 | 0.2 |
| IL-3 | 1.2 | 0.8 | 0.8 | 0.7 | 0.1 | 0.8 | 0 | 0.1 | 0 | 0 | 0.2 | 0.1 | 0.5 | 0 | 0.5 |
| SCF | 1.2 | 0.6 | 0.7 | 0.5 | 0.1 | 0.3 | NA | 0.1 | 0.1 | 0 | 0.5 | 0.1 | 0.5 | 0 | 0.7 |
Cells were incubated for 72 hours in the presence of the indicated growth factors. Epo, 1 U/mL; IL-3, 2.5 ng/mL; SCF, 100 ng/mL.
Abbreviation: NA, not available.
Case of MDS (see Table 1).