Table 2. Platelet Integrin α 2 β 1... | American Society of Hematology

Table 2.

Platelet Integrin α₂β₁

Family No. 1	807 Alleles	Antigen (Radioimmunoassay)^*		Activity^†
		AP2 (anti-α_IIbβ₃)	6F1 (anti-α₂β₁)	Type-I Collagen	Type-III Collagen	Fibronectin
Mother (no. 1)	CC	52,714 ± 442	933 ± 34	0.7 ± 0.2	3.5 ± 0.2	11.1 ± 1.2
Father (no. 15)	TT	49,102 ± 547	2,325 ± 122	16.8 ± 1.2	18.7 ± 0.6	9.1 ± 0.6
Son (no. 16)	CT	49,613 ± 877	1,612 ± 213	6.1 ± 0.7	8.7 ± 1.3	10.0 ± 1.2
Son (no. 17)	CT	49,311 ± 342	1,606 ± 127	2.2 ± 0.6	4.3 ± 1.0	8.9 ± 0.8

Family No. 2	807 Alleles	Antigen (Flow Cytometry)^‡		Activity^†
		AP2 (anti-α_IIbβ₃)	6F1 (anti-α₂β₁)	Type-I Collagen	Type-III Collagen	Fibronectin

Family No. 1	807 Alleles	Antigen (Radioimmunoassay)^*		Activity^†
		AP2 (anti-α_IIbβ₃)	6F1 (anti-α₂β₁)	Type-I Collagen	Type-III Collagen	Fibronectin
Mother (no. 1)	CC	52,714 ± 442	933 ± 34	0.7 ± 0.2	3.5 ± 0.2	11.1 ± 1.2
Father (no. 15)	TT	49,102 ± 547	2,325 ± 122	16.8 ± 1.2	18.7 ± 0.6	9.1 ± 0.6
Son (no. 16)	CT	49,613 ± 877	1,612 ± 213	6.1 ± 0.7	8.7 ± 1.3	10.0 ± 1.2
Son (no. 17)	CT	49,311 ± 342	1,606 ± 127	2.2 ± 0.6	4.3 ± 1.0	8.9 ± 0.8

Family No. 2	807 Alleles	Antigen (Flow Cytometry)^‡		Activity^†
		AP2 (anti-α_IIbβ₃)	6F1 (anti-α₂β₁)	Type-I Collagen	Type-III Collagen	Fibronectin

Mother (no. 18)

49.35

1.28

5.5 ± 0.4

12.1 ± 0.4

13.5 ± 3.2

Father (no. 19)

51.01

4.15

17.5 ± 1.1

29.9 ± 1.3

14.0 ± 1.3

Son (no. 20)

48.11

3.54

17.9 ± 1.2

25.2 ± 1.1

9.9 ± 2.9

Daughter (no. 21)

44.91

1.42

3.4 ± 0.9

11.2 ± 1.0

10.1 ± 1.0

The values shown are the number of molecules bound per platelet (mean ± SD; n = 3).

The values shown are the number of platelets × 10⁻⁵ bound as indicated (mean ± SD; n = 3 for family no. 1 and n = 2 for family no. 2).

The values shown are MFIs.