Effects of MCMV Infection on the Number of Hematopoietic Progenitor Cells in Bone Marrow
| Days After . | No. of Bone . | Lin−c-kit+ Cells . | Lin−CD34+ Cells . | ||
|---|---|---|---|---|---|
| Infection . | Marrow Cells . | Percent No. . | Total No. . | Percent No. . | Total No. . |
| . | (×107) . | (%) . | (×105) . | (%) . | (×105) . |
| 0 | 3.62 ± 0.20 | 1.58 ± 0.18 | 5.62 ± 0.74 | 1.77 ± 0.05 | 6.41 ± 0.35 |
| 1 | 3.23 ± 0.31 | 1.53 ± 0.06 | 4.95 ± 0.57 | ND | ND |
| 3 | 2.05 ± 0.27* | 1.24 ± 0.06 | 2.55 ± 0.28* | 1.59 ± 0.05 | 3.26 ± 0.42* |
| 5 | 2.01 ± 0.08* | 1.36 ± 0.11 | 2.76 ± 0.13* | ND | ND |
| 7 | 3.67 ± 0.28 | 1.51 ± 0.03 | 5.55 ± 0.30 | ND | ND |
| 14 | 5.13 ± 0.43 | 1.58 ± 0.10 | 8.02 ± 0.66† | ND | ND |
| Days After . | No. of Bone . | Lin−c-kit+ Cells . | Lin−CD34+ Cells . | ||
|---|---|---|---|---|---|
| Infection . | Marrow Cells . | Percent No. . | Total No. . | Percent No. . | Total No. . |
| . | (×107) . | (%) . | (×105) . | (%) . | (×105) . |
| 0 | 3.62 ± 0.20 | 1.58 ± 0.18 | 5.62 ± 0.74 | 1.77 ± 0.05 | 6.41 ± 0.35 |
| 1 | 3.23 ± 0.31 | 1.53 ± 0.06 | 4.95 ± 0.57 | ND | ND |
| 3 | 2.05 ± 0.27* | 1.24 ± 0.06 | 2.55 ± 0.28* | 1.59 ± 0.05 | 3.26 ± 0.42* |
| 5 | 2.01 ± 0.08* | 1.36 ± 0.11 | 2.76 ± 0.13* | ND | ND |
| 7 | 3.67 ± 0.28 | 1.51 ± 0.03 | 5.55 ± 0.30 | ND | ND |
| 14 | 5.13 ± 0.43 | 1.58 ± 0.10 | 8.02 ± 0.66† | ND | ND |
The mice were inoculated with 1 × 105 PFU of MCMV. The population of the Lin−c-kit+ and Lin−CD34+ cells in the bone marrow cells were examined by flow cytometry. The results from three to four mice were expressed as the mean ± SEM.
Abbreviation: ND, not done.
Significant decrease versus uninfected control mice (P < .01).
Significant increase versus uninfected control mice (P < .01).