Distribution of Mutations in the 5′ Noncoding Regions and Gross Rearrangements of BCL-6 in Systemic AIDS-NHL
| Histology . | BCL-6 Mutations . | BCL-6 Rearrangements . |
|---|---|---|
| . | (positive/tested) . | (positive/tested) . |
| AIDS-BL | 12/20* | 0/16 |
| AIDS-DLCL | 10/15 | 3/12 |
| AIDS-ALCL | 2/3 | 0/3 |
| AIDS-BCBL | 1/5† | 0/1 |
| Histology . | BCL-6 Mutations . | BCL-6 Rearrangements . |
|---|---|---|
| . | (positive/tested) . | (positive/tested) . |
| AIDS-BL | 12/20* | 0/16 |
| AIDS-DLCL | 10/15 | 3/12 |
| AIDS-ALCL | 2/3 | 0/3 |
| AIDS-BCBL | 1/5† | 0/1 |
Abbreviations: AIDS-BL, AIDS-related Burkitt's lymphoma; AIDS-DLCL, AIDS-related diffuse large cell lymphoma; AIDS-ALCL, AIDS-related anaplastic large cell lymphoma; AIDS-BCBL, AIDS-related body-cavity-based lymphoma.
AIDS-BL cases harboring mutations of the 5′ non-coding regions of BCL-6 included 6 of 11 biopsy specimens and 6 of 9 tumor cell lines.
The case of AIDS-BCBL carrying mutations of the 5′ noncoding regions of BCL-6 is represented by a cell line.