Hematological Data for Blood From 4-Month-Old MHOAH Control and Transgenic Sickle Cell Mice
| Indices . | Mice . | |||
|---|---|---|---|---|
| . | MHOAH . | M-Tg98Ru . | M-Tg58Ru . | Tg58 × Tg98 . |
| WBC (×106/mL) | 6.9 ± 0.6 | 9.7 ± 3.2 | 18.9 ± 1.6* | 16.8 ± 1.9* |
| RBC (×109/mL) | 11.4 ± 0.2 | 11.5 ± 0.4 | 9.9 ± 0.3* | 10.8 ± 0.4* |
| Reticulocytes (%) | 2.5 ± 0.3 | 5.8 ± 0.5* | 14.8 ± 0.5* | 13.3 ± 0.5* |
| HGB (g/dL) | 15.7 ± 0.2 | 14.9 ± 0.8 | 12.6 ± 0.4* | 14.1 ± 0.3* |
| HCT (%) | 49.7 ± 0.7 | 50.7 ± 0.9 | 45.4 ± 1.4* | 48.5 ± 1.1 |
| MCV (fL) | 43.4 ± 0.7 | 40.6 ± 0.8 | 46.3 ± 0.7 | 45.3 ± 1.3 |
| MCH (pg) | 13.8 ± 0.2 | 13.0 ± 0.4* | 12.8 ± 0.2* | 13.1 ± 0.4* |
| MCHC (g/dL) | 31.6 ± 0.3 | 29.4 ± 1.0* | 27.8 ± 0.4* | 29.0 ± 0.3 |
| HbS Ant (%) | 0 | 13.4 ± 0.3 | 15.7 ± 0.6 | 37.9 ± 0.3 |
| Misshapen RBC (%) | 0-1 | 1-3 | 10-15 | 25-35 |
| Induced SC (%) | 0 | 0-1 | 1-5 | 30-50 |
| P50 value | 24.5 ± 0.2 | 36.0 ± 0.5 | 31.6 ± 1.6 | 33.3 ± 0.8 |
| Indices . | Mice . | |||
|---|---|---|---|---|
| . | MHOAH . | M-Tg98Ru . | M-Tg58Ru . | Tg58 × Tg98 . |
| WBC (×106/mL) | 6.9 ± 0.6 | 9.7 ± 3.2 | 18.9 ± 1.6* | 16.8 ± 1.9* |
| RBC (×109/mL) | 11.4 ± 0.2 | 11.5 ± 0.4 | 9.9 ± 0.3* | 10.8 ± 0.4* |
| Reticulocytes (%) | 2.5 ± 0.3 | 5.8 ± 0.5* | 14.8 ± 0.5* | 13.3 ± 0.5* |
| HGB (g/dL) | 15.7 ± 0.2 | 14.9 ± 0.8 | 12.6 ± 0.4* | 14.1 ± 0.3* |
| HCT (%) | 49.7 ± 0.7 | 50.7 ± 0.9 | 45.4 ± 1.4* | 48.5 ± 1.1 |
| MCV (fL) | 43.4 ± 0.7 | 40.6 ± 0.8 | 46.3 ± 0.7 | 45.3 ± 1.3 |
| MCH (pg) | 13.8 ± 0.2 | 13.0 ± 0.4* | 12.8 ± 0.2* | 13.1 ± 0.4* |
| MCHC (g/dL) | 31.6 ± 0.3 | 29.4 ± 1.0* | 27.8 ± 0.4* | 29.0 ± 0.3 |
| HbS Ant (%) | 0 | 13.4 ± 0.3 | 15.7 ± 0.6 | 37.9 ± 0.3 |
| Misshapen RBC (%) | 0-1 | 1-3 | 10-15 | 25-35 |
| Induced SC (%) | 0 | 0-1 | 1-5 | 30-50 |
| P50 value | 24.5 ± 0.2 | 36.0 ± 0.5 | 31.6 ± 1.6 | 33.3 ± 0.8 |
Values statistically different from the MHOAH control (<.05) using the Student's t-test. Values are the mean ± standard error of mean of 12 to 23 mice per group.