Prognostic Significance of Antigen Expression in Childhood B-Precursor ALL by Univariate Analysis (P values)
| Antigen . | All . | Intensity . | ||
|---|---|---|---|---|
| . | Patients . | All . | Standard-Risk . | Poor-Risk . |
| . | > 20% . | Patients . | Patients . | Patients . |
| CD10 | .08 | .14 | .28 | .28 |
| CD19 | * | .65 | .11 | .69 |
| CD20 | .01 | .005 | .34 | .01 |
| CD22 | <.001 | .33 | .38 | .54 |
| HLA-DR | * | .63 | .84 | .76 |
| CD34 | .92 | .60 | .73 | .48 |
| CD9 | .91 | .18 | .81 | .18 |
| CD24 | .28 | .68 | .53 | .04 |
| CD45 | .81 | <.0001 | .08 | .0001 |
| Antigen . | All . | Intensity . | ||
|---|---|---|---|---|
| . | Patients . | All . | Standard-Risk . | Poor-Risk . |
| . | > 20% . | Patients . | Patients . | Patients . |
| CD10 | .08 | .14 | .28 | .28 |
| CD19 | * | .65 | .11 | .69 |
| CD20 | .01 | .005 | .34 | .01 |
| CD22 | <.001 | .33 | .38 | .54 |
| HLA-DR | * | .63 | .84 | .76 |
| CD34 | .92 | .60 | .73 | .48 |
| CD9 | .91 | .18 | .81 | .18 |
| CD24 | .28 | .68 | .53 | .04 |
| CD45 | .81 | <.0001 | .08 | .0001 |
Analysis of failure rates of patients in different groups was conducted with the log-rank test. In the column marked “v 20%,” patients were considered positive for each marker if 20% of blasts were positive; in columns marked “intensity,” patient populations were determined based on intensity distributions. Standard-risk and poor-risk patients were treated on study protocols 9005 and 9006, respectively.
Only 3 patients were CD19− and 2 patients HLA-DR−.