Table 4.

Cell-Cycle Distribution of CD34+ Cells

Source of Cells% G0% G1% S% G2MRNA-IG1% APO
BM (D0) 22.8 ± 7 61.9 ± 6 13.8 ± 2 1.7 ± 0.5 20.3 ± 0.7 3.7 ± 1 
BM (D5) 20.3 ± 10  48 ± 44-150  26 ± 44-150  3 ± 14-150 21.6 ± 5  2 ± 14-150 
PB (D5) 19.2 ± 4  80 ± 5*† 0.6 ± 0.3*† 0.1 ± 0.1*† 16.3 ± 0.5*† 2.4 ± 0.54-150 
Source of Cells% G0% G1% S% G2MRNA-IG1% APO
BM (D0) 22.8 ± 7 61.9 ± 6 13.8 ± 2 1.7 ± 0.5 20.3 ± 0.7 3.7 ± 1 
BM (D5) 20.3 ± 10  48 ± 44-150  26 ± 44-150  3 ± 14-150 21.6 ± 5  2 ± 14-150 
PB (D5) 19.2 ± 4  80 ± 5*† 0.6 ± 0.3*† 0.1 ± 0.1*† 16.3 ± 0.5*† 2.4 ± 0.54-150 

The results are expressed as the mean ± SEM of 12 different experiments. RNA-IG1 defines the RNA content of G1 cells and it is determined as the ratio of the mean of RNA content of G1 cells of study samples times 10, divided by the median RNA content of control lymphocytes.

Abbreviation: APO, apoptotic.

F4-150

Statistically significant versus baseline BM (D0) samples.

F4-151

Statistically significant versus day-5 BM (D5) samples.

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