Prognostic Factors Associated With Outcomes Following PMRD Allo-BMT
| Outcome . | Prognostic Factor3-150 . | Reference . | Risk Level . | RR3-151 . | 95% CI . | P Value . |
|---|---|---|---|---|---|---|
| . | . | Level . | (unfavorable) . | . | . | . |
| . | . | (favorable) . | . | . | . | . |
| WBC 1,000 engraftment3-152 | TBI dose | 1,500 cGy | 1,332 cGy | 0.33 | (0.18, 0.59) | <.001 |
| Rejection mismatch | <3-Ag | 3-Ag | 0.29 | (0.14, 0.57) | <.001 | |
| Degree of TCDρ | Less | More | 0.45 | (0.21, 0.97) | .043 | |
| Stable engraftment∥ | TBI dose | 1,500 cGy | 1,332 cGy | 0.46 | (0.27, 0.80) | .005 |
| Rejection mismatch | <3-Ag | 3-Ag | 0.38 | (0.29, 0.70) | .002 | |
| Acute GVHD III-IV3-154 | T-cell doseρ | Lower | Higher | 7.17 | (0.94, 54.98) | .058 |
| Chronic GVHD3-154 | TBI dose | 1,332 cGy | 1,500 cGy | 3.54 | (1.26, 9.89) | .016 |
| Relapse3-154 | Disease category | Low risk | High risk | 3.57 | (1.04, 12.20) | .043 |
| Treatment failure¶# | Disease category | Low risk | High risk | 2.17 | (1.05, 4.51) | .037 |
| Death3-154 | Disease category | Low risk | High risk | 2.10 | (1.01, 4.35) | .046 |
| Outcome . | Prognostic Factor3-150 . | Reference . | Risk Level . | RR3-151 . | 95% CI . | P Value . |
|---|---|---|---|---|---|---|
| . | . | Level . | (unfavorable) . | . | . | . |
| . | . | (favorable) . | . | . | . | . |
| WBC 1,000 engraftment3-152 | TBI dose | 1,500 cGy | 1,332 cGy | 0.33 | (0.18, 0.59) | <.001 |
| Rejection mismatch | <3-Ag | 3-Ag | 0.29 | (0.14, 0.57) | <.001 | |
| Degree of TCDρ | Less | More | 0.45 | (0.21, 0.97) | .043 | |
| Stable engraftment∥ | TBI dose | 1,500 cGy | 1,332 cGy | 0.46 | (0.27, 0.80) | .005 |
| Rejection mismatch | <3-Ag | 3-Ag | 0.38 | (0.29, 0.70) | .002 | |
| Acute GVHD III-IV3-154 | T-cell doseρ | Lower | Higher | 7.17 | (0.94, 54.98) | .058 |
| Chronic GVHD3-154 | TBI dose | 1,332 cGy | 1,500 cGy | 3.54 | (1.26, 9.89) | .016 |
| Relapse3-154 | Disease category | Low risk | High risk | 3.57 | (1.04, 12.20) | .043 |
| Treatment failure¶# | Disease category | Low risk | High risk | 2.17 | (1.05, 4.51) | .037 |
| Death3-154 | Disease category | Low risk | High risk | 2.10 | (1.01, 4.35) | .046 |
Abbreviations: PMRD, partially mismatched related donor; allo-BMT, allogeneic bone marrow transplant; RR, relative risk; WBC, white blood cell; TBI, total body irradiation; Ag, antigen; TCD, T-cell depletion; GVHD, graft-versus-host disease.
Only prognostic factors that were significant at the 0.05 level in multivariate analysis are shown.
Relative risk (RR) applies to the unfavorable level of the prognostic factor compared with the favorable level used as the reference group.
Engraftment to WBC count of ≥1,000/μL uses data from initial transplants only. RR < 1 indicates lower probability of engraftment and/or delayed engraftment for patients with an unfavorable level of the given prognostic factor.
ρ Degree of T-cell depletion and T-cell dose were entered as continuous variables in log10 units.
∥ Stable engraftment refers to achievement of WBC count of ≥1,000/μL using data for all patients receiving one or more transplants. RR < 1 indicates lower probability of engraftment and/or delayed engraftment for patients with an unfavorable level of the given prognostic factor.
RR > 1 indicates higher risk of the adverse event for patients with an unfavorable level of the indicated prognostic factor.
Treatment failure refers to relapse or death.