Experimental Groups
Exp. No. . | Sex . | Weight (kg) . | E coli Infused (CFU/kg × 1010) . | E coli Colony Count at T = 2 h (CFU/mL × 106) . | C4bBP (mg/kg) . | 7E3 F(ab′)2 (mg/kg) . | Survival (h) . |
---|---|---|---|---|---|---|---|
Group 1 — C4bBP alone | |||||||
1 | F | 4.6 | — | — | 20 | — | 168 |
2 | M | 5.2 | — | — | 20 | — | 168 |
3 | F | 8.2 | — | — | 20 | — | 168 |
Average | — | 6.0 | — | — | 20 | — | 168 |
SE | — | 0.4 | — | — | 0 | — | 0 |
Group 2-Sublethal E coli alone | |||||||
4 | M | 6.1 | 0.93 | 3.20 | — | — | 168 |
5 | M | 7.1 | 0.93 | 1.04 | — | — | 168 |
6 | F | 14.6 | 0.84 | 7.60 | — | — | 168 |
7 | F | 6.4 | 1.07 | 0.28 | — | — | 168 |
8 | M | 5.7 | 1.13 | 0.61 | — | — | 168 |
Average | — | 7.9 | 0.98 | 2.54 | — | — | 168 |
SE | — | 1.67 | 0.05 | 0.28 | — | — | 0 |
Group 3-Sublethal E coli plus C4bBP (“untreated”) | |||||||
9 | M | 3.9 | 1.24 | 0.48 | 20 | — | 25(s)* |
10 | M | 2.7 | 1.71 | 0.87 | 20 | — | 24(s) |
11 | F | 2.3 | 0.76 | 0.03 | 20 | — | 23(s) |
12 | M | 5.2 | 0.55 | 0.11 | 20 | — | 14 |
13 | M | 7.5 | 1.34 | 0.73 | 20 | — | 30(s) |
Average | — | 4.32 | 1.12 | 0.44 | 20 | — | — |
SE | — | 0.94 | 0.20 | 0.17 | 0 | — | — |
Group 4-7E3 F(ab′)2 plus sublethal E coli plus C4bBP (“treated”) | |||||||
14 | F | 7.3 | 1.2 | 0.92 | 20 | 0.25 bolus | 48(s) |
0.25 infusion | |||||||
15 | F | 7.7 | 1.1 | 0.26 | 20 | 0.35 bolus | 72(s) |
0.35 infusion | |||||||
16 | M | 6.8 | 1.2 | 0.61 | 20 | 0.35 bolus | 48(s) |
0.35 infusion | |||||||
17 | F | 8.2 | 1.3 | 0.22 | 20 | 0.35 bolus | 7 days(s) |
0.35 infusion | |||||||
Average | — | 7.5 | 1.20 | 0.50 | 20 | — | — |
SE | — | 0.30 | 0.04 | 0.16 | 0 | — | — |
Exp. No. . | Sex . | Weight (kg) . | E coli Infused (CFU/kg × 1010) . | E coli Colony Count at T = 2 h (CFU/mL × 106) . | C4bBP (mg/kg) . | 7E3 F(ab′)2 (mg/kg) . | Survival (h) . |
---|---|---|---|---|---|---|---|
Group 1 — C4bBP alone | |||||||
1 | F | 4.6 | — | — | 20 | — | 168 |
2 | M | 5.2 | — | — | 20 | — | 168 |
3 | F | 8.2 | — | — | 20 | — | 168 |
Average | — | 6.0 | — | — | 20 | — | 168 |
SE | — | 0.4 | — | — | 0 | — | 0 |
Group 2-Sublethal E coli alone | |||||||
4 | M | 6.1 | 0.93 | 3.20 | — | — | 168 |
5 | M | 7.1 | 0.93 | 1.04 | — | — | 168 |
6 | F | 14.6 | 0.84 | 7.60 | — | — | 168 |
7 | F | 6.4 | 1.07 | 0.28 | — | — | 168 |
8 | M | 5.7 | 1.13 | 0.61 | — | — | 168 |
Average | — | 7.9 | 0.98 | 2.54 | — | — | 168 |
SE | — | 1.67 | 0.05 | 0.28 | — | — | 0 |
Group 3-Sublethal E coli plus C4bBP (“untreated”) | |||||||
9 | M | 3.9 | 1.24 | 0.48 | 20 | — | 25(s)* |
10 | M | 2.7 | 1.71 | 0.87 | 20 | — | 24(s) |
11 | F | 2.3 | 0.76 | 0.03 | 20 | — | 23(s) |
12 | M | 5.2 | 0.55 | 0.11 | 20 | — | 14 |
13 | M | 7.5 | 1.34 | 0.73 | 20 | — | 30(s) |
Average | — | 4.32 | 1.12 | 0.44 | 20 | — | — |
SE | — | 0.94 | 0.20 | 0.17 | 0 | — | — |
Group 4-7E3 F(ab′)2 plus sublethal E coli plus C4bBP (“treated”) | |||||||
14 | F | 7.3 | 1.2 | 0.92 | 20 | 0.25 bolus | 48(s) |
0.25 infusion | |||||||
15 | F | 7.7 | 1.1 | 0.26 | 20 | 0.35 bolus | 72(s) |
0.35 infusion | |||||||
16 | M | 6.8 | 1.2 | 0.61 | 20 | 0.35 bolus | 48(s) |
0.35 infusion | |||||||
17 | F | 8.2 | 1.3 | 0.22 | 20 | 0.35 bolus | 7 days(s) |
0.35 infusion | |||||||
Average | — | 7.5 | 1.20 | 0.50 | 20 | — | — |
SE | — | 0.30 | 0.04 | 0.16 | 0 | — | — |
(s) = Sacrificed.