Lack of Effect of Repeated Growth Factor Injections on the Cell Cycle Status of Human CFC in NOD/SCID Mice Transplanted With Human Marrow Cells
| Time Posttransplant . | Growth Factors . | % in S-Phase . | |
|---|---|---|---|
| . | . | Mature BFU-E/CFU-GM . | Primitive BFU-E/CFU-GM . |
| Week 5 | − | 46 ± 4 | 57 ± 4 |
| + | 43 ± 3 | 70 ± 5 | |
| Week 10 | − | 0 ± 5 | 4 ± 2 |
| + | 14 ± 6 | 0 ± 4 | |
| Week 16 | − | 0 ± 5 | 0 |
| + | 0 ± 9 | 7 ± 3 | |
| Time Posttransplant . | Growth Factors . | % in S-Phase . | |
|---|---|---|---|
| . | . | Mature BFU-E/CFU-GM . | Primitive BFU-E/CFU-GM . |
| Week 5 | − | 46 ± 4 | 57 ± 4 |
| + | 43 ± 3 | 70 ± 5 | |
| Week 10 | − | 0 ± 5 | 4 ± 2 |
| + | 14 ± 6 | 0 ± 4 | |
| Week 16 | − | 0 ± 5 | 0 |
| + | 0 ± 9 | 7 ± 3 | |
Growth factors (10 μg SF, 6 μg IL-3, 6 μg GM-CSF, 10 U Ep) injected 3×/mouse/week for 2 weeks before being killed.