Multilineage Engraftment in the BM of Mice Transplanted With SRC in Limiting Doses
| Mouse . | CD19+ cells (%*) . | BFU-E† . | CFC† . |
|---|---|---|---|
| C15.6 | 0.2 | 1485 | 14,108 |
| C16.2 | 0.1 | 312 | 3,978 |
| C16.7 | 2.4 | 855 | 5,580 |
| C16.8 | 0.2 | 54 | 216 |
| C16.9 | 1.8 | 0 | 1,953 |
| C16.11 | 0.7 | 68 | 1,080 |
| C16.12 | 0.2 | 462 | 1,596 |
| C18.1 | 26.0 | TNTC | TNTC |
| C18.3 | 0.2 | 0 | 2,184 |
| C18.5 | 0.8 | 81 | 324 |
| C18.9 | 7.9 | 23 | 1,685 |
| C19.11 | 2.2 | 2925 | 8,700 |
| Mouse . | CD19+ cells (%*) . | BFU-E† . | CFC† . |
|---|---|---|---|
| C15.6 | 0.2 | 1485 | 14,108 |
| C16.2 | 0.1 | 312 | 3,978 |
| C16.7 | 2.4 | 855 | 5,580 |
| C16.8 | 0.2 | 54 | 216 |
| C16.9 | 1.8 | 0 | 1,953 |
| C16.11 | 0.7 | 68 | 1,080 |
| C16.12 | 0.2 | 462 | 1,596 |
| C18.1 | 26.0 | TNTC | TNTC |
| C18.3 | 0.2 | 0 | 2,184 |
| C18.5 | 0.8 | 81 | 324 |
| C18.9 | 7.9 | 23 | 1,685 |
| C19.11 | 2.2 | 2925 | 8,700 |
NOD/SCID mice were transplanted with 1 × 106 mononuclear CB cells and the murine BM was analyzed after 6 weeks by flow cytometry to assess the presence of human CD19+ B-lymphoid cells, and by plating in methylcellulose cultures to assess the presence of human myeloerythroid progenitors.
Abbreviations: BFU-E, burst-forming unit-erythroid; CFC includes granulocyte, macrophage, and granulocyte-macrophage colony-forming cells; TNTC, too numerous to count.
Percentage of total leukocytes in the murine BM.
Number per 6 bones (2 femurs, 2 tibiae, and 2 iliac crests).