The Average Values and Standard Deviations of the AA, BB, ABm , CA, and CB Distributions in Interphase Nuclei of Control and Irradiated Lymphocytes
| Phase of Cell Cycle . | Irradiation (Gy) . | AA (% of R)
. | BB (% of R)
. | AB m (% of R)*
. | CA (% of R)
. | CB (% of R)
. |
|---|---|---|---|---|---|---|
| G0 | 0 | 57.3 ± 1.5 (55.8)† | 53.4 ± 1.3 (52.2) | 24.0 ± 0.9 (25.4) | 34.9 ± 0.7 | 37.4 ± 0.7 |
| G1 | 0 | 63.0 ± 1.8 (59.3) | 57.9 ± 1.7 (55.2) | 34.5 ± 1.1 (30.2)‡ | 43.5 ± 0.8 | 42.9 ± 0.9 |
| S(G2 ) | 0 | 61.9 ± 1.8 (60.9) | 59.4 ± 1.5 (58.7) | 36.0 ± 1.0 (31.7)‡ | 45.6 ± 0.7 | 43.3 ± 0.7 |
| G1 | 5 | 60.2 ± 1.4 (54.2) | 59.8 ± 1.7 (55.5) | 26.6 ± 1.0 (28.6) | 39.6 ± 0.8 | 40.0 ± 0.9 |
| S(G2 ) | 5 | 52.1 ± 1.2 (50.9) | 49.7 ± 1.4 (47.1) | 28.4 ± 0.9 (27.4) | 37.3 ± 0.7 | 35.1 ± 0.7 |
| G1 (5 Gy/0 Gy) | 0.957 ± 0.049 | 1.033 ± 0.058 | 0.772 ± 0.052ρ | 0.911 ± 0.0352-155 | 0.933 ± 0.0382-155 | |
| S(G2 ) (5 Gy/0 Gy) | 0.842 ± 0.044ρ | 0.837 ± 0.044ρ | 0.789 ± 0.047ρ | 0.818 ± 0.027ρ | 0.811 ± 0.031ρ | |
| 0 Gy (G1 /S) | 1.017 ± 0.058 | 0.975 ± 0.052 | 0.957 ± 0.056 | 0.954 ± 0.031 | 0.990 ± 0.037 | |
| 5 Gy (G1 /S) | 1.156 ± 0.053ρ | 1.204 ± 0.0672-155 | 0.936 ± 0.066 | 1.062 ± 0.040 | 1.139 ± 0.048 | |
| Phase of Cell Cycle . | Irradiation (Gy) . | AA (% of R)
. | BB (% of R)
. | AB m (% of R)*
. | CA (% of R)
. | CB (% of R)
. |
|---|---|---|---|---|---|---|
| G0 | 0 | 57.3 ± 1.5 (55.8)† | 53.4 ± 1.3 (52.2) | 24.0 ± 0.9 (25.4) | 34.9 ± 0.7 | 37.4 ± 0.7 |
| G1 | 0 | 63.0 ± 1.8 (59.3) | 57.9 ± 1.7 (55.2) | 34.5 ± 1.1 (30.2)‡ | 43.5 ± 0.8 | 42.9 ± 0.9 |
| S(G2 ) | 0 | 61.9 ± 1.8 (60.9) | 59.4 ± 1.5 (58.7) | 36.0 ± 1.0 (31.7)‡ | 45.6 ± 0.7 | 43.3 ± 0.7 |
| G1 | 5 | 60.2 ± 1.4 (54.2) | 59.8 ± 1.7 (55.5) | 26.6 ± 1.0 (28.6) | 39.6 ± 0.8 | 40.0 ± 0.9 |
| S(G2 ) | 5 | 52.1 ± 1.2 (50.9) | 49.7 ± 1.4 (47.1) | 28.4 ± 0.9 (27.4) | 37.3 ± 0.7 | 35.1 ± 0.7 |
| G1 (5 Gy/0 Gy) | 0.957 ± 0.049 | 1.033 ± 0.058 | 0.772 ± 0.052ρ | 0.911 ± 0.0352-155 | 0.933 ± 0.0382-155 | |
| S(G2 ) (5 Gy/0 Gy) | 0.842 ± 0.044ρ | 0.837 ± 0.044ρ | 0.789 ± 0.047ρ | 0.818 ± 0.027ρ | 0.811 ± 0.031ρ | |
| 0 Gy (G1 /S) | 1.017 ± 0.058 | 0.975 ± 0.052 | 0.957 ± 0.056 | 0.954 ± 0.031 | 0.990 ± 0.037 | |
| 5 Gy (G1 /S) | 1.156 ± 0.053ρ | 1.204 ± 0.0672-155 | 0.936 ± 0.066 | 1.062 ± 0.040 | 1.139 ± 0.048 | |
The distances are shown as a percentage of the nuclear radius (R).
Abbreviations: AA, average distance ABL-ABL;BB, average distance BCR-BCR;ABm , average minimum distance ABL-BCR;CA, average distance center of nucleus-to-ABL;CB, average distance center of nucleus-to-BCR.
Minimum of 4 distances between 2D projections of ABL and BCR genes in a nucleus is taken.
Theoretical values (in parentheses); the standard errors of the theoretical values (derived from the standard errors of the average center-to-gene distances) are less than that of experimental ones.
Theoretical value is significantly different from the experimental one (P < .05).
ρ Significantly different from 1 (P < .005).
Significantly different from 1 (P < .05).