Transfer of Escapee Tumor
| Cells Injected . | No. of Dormant Mice/Total No. of Recipients (day to splenomegaly ± SD) . | |||
|---|---|---|---|---|
| . | Nonimmune (control) . | ID-Immune* . | SCID + Anti-μ . | Variant (0-4+)† . |
| BCL1 control | 0/14 (28 ± 3) | 19/28 (99 ± 47) | ND | |
| Id-immune escapee no. | ||||
| 1 | 0/5 (25 ± 0) | 0/11 (47 ± 22) | ND | +++ |
| 2 | 0/5 (25 ± 0) | 4/12 (67 ± 27) | ND | ++ |
| 3 | 0/5 (30 ± 0) | 0/9 (30 ± 0) | ND | ++++ |
| 4 | 0/5 (47 ± 5) | 5/10 (82 ± 43) | ND | 0 |
| 5 | 2/5 (62 ± 8) | 6/10 (79 ± 44) | ND | 0 |
| 6 | 0/5 (28 ± 0) | 1/9 (43 ± 16) | ND | +++ |
| 7 | 0/4 (29 ± 2) | 6/10 (70 ± 33) | ND | 0 |
| 8 | 0/5 (28 ± 0) | 3/10 (44 ± 22) | ND | ++ |
| SCID escapee no. | ||||
| 9 | 0/5 (34 ± 6) | 0/9 (36 ± 7) | 0/10 (39 ± 2) | ++++ |
| 10 | 0/5 (28 ± 0) | 0/10 (33 ± 4) | 0/10 (39 ± 2) | ++++ |
| Cells Injected . | No. of Dormant Mice/Total No. of Recipients (day to splenomegaly ± SD) . | |||
|---|---|---|---|---|
| . | Nonimmune (control) . | ID-Immune* . | SCID + Anti-μ . | Variant (0-4+)† . |
| BCL1 control | 0/14 (28 ± 3) | 19/28 (99 ± 47) | ND | |
| Id-immune escapee no. | ||||
| 1 | 0/5 (25 ± 0) | 0/11 (47 ± 22) | ND | +++ |
| 2 | 0/5 (25 ± 0) | 4/12 (67 ± 27) | ND | ++ |
| 3 | 0/5 (30 ± 0) | 0/9 (30 ± 0) | ND | ++++ |
| 4 | 0/5 (47 ± 5) | 5/10 (82 ± 43) | ND | 0 |
| 5 | 2/5 (62 ± 8) | 6/10 (79 ± 44) | ND | 0 |
| 6 | 0/5 (28 ± 0) | 1/9 (43 ± 16) | ND | +++ |
| 7 | 0/4 (29 ± 2) | 6/10 (70 ± 33) | ND | 0 |
| 8 | 0/5 (28 ± 0) | 3/10 (44 ± 22) | ND | ++ |
| SCID escapee no. | ||||
| 9 | 0/5 (34 ± 6) | 0/9 (36 ± 7) | 0/10 (39 ± 2) | ++++ |
| 10 | 0/5 (28 ± 0) | 0/10 (33 ± 4) | 0/10 (39 ± 2) | ++++ |
Abbreviation: ND, not done.
The average day to splenomegaly of the escapees from Id-immune mice reinjected into Id-immune animals was compared with the average day to splenomegaly of control BCL1 in Id-immune animals. Five of 8 escapees had a statistically significant decrease in the average day to splenomegaly as determined by the Student's t-test (escapee no. 1 with P = .0013, escapee no. 2 with P = .018, escapee no. 3 with P = .0037, escapee no. 6 with P = .0002, and escapee no. 8 with P = .0001).
Estimation of susceptibility (0-4+) based on both proportion of dormant mice and interval before splenomegaly of challenged Id-immune recipient.