Content of Human Neutrophil Granules and Secretory Vesicles
| Azurophil Granules . | Specific Granules . | Gelatinase Granules . | Secretory Vesicles . |
|---|---|---|---|
| Membrane | |||
| CD6359 289 | |||
| CD68290 | |||
| V-type H+-ATPase291 | Membrane | ||
| CD11b64,104 | |||
| CD15 antigens305 | |||
| CD66306 | |||
| CD67306 | |||
| Cytochrome b55817,52,105 | |||
| fMLP-R131,307 308 | |||
| Fibronectin-R309 | |||
| G-proteinα-subunit310 311 | |||
| Laminin-R309 | |||
| NB 1 antigen312 | |||
| 19-kD protein313 | |||
| 155-kD protein314 | |||
| Rap1, Rap2315,316 | |||
| SCAMP170 | |||
| Thrombospondin-R317 | |||
| TNF-R318 | |||
| Urokinase-type plasminogen activator-R319 | |||
| VAMP-2170 | |||
| Vitronectin-R309 | Membrane | ||
| CD11b64,109,327-330 | |||
| Cytochrome b55820 | |||
| Diacylglycerol-deacylating enzyme331 | |||
| fMLP-R109 131 | |||
| SCAMP170 | |||
| Urokinase-type plasminogen activator-R319 | |||
| VAMP-2170 | |||
| V-type H+-ATPase291 | Membrane | ||
| Alkaline phosphatase23-26 66 | |||
| CR165 | |||
| Cytochrome b55862,333 | |||
| CD11b62,64 | |||
| CD14334 | |||
| CD1663 334 * | |||
| fMLP-R131 | |||
| SCAMP170 | |||
| Urokinase-type plasminogen activator-R319 | |||
| V-type H+-ATPase291 | |||
| VAMP-2170 | |||
| CD10, CD13, CD45335 * | |||
| C1q-receptor336 * | |||
| DAF60 * | |||
| Matrix | |||
| Acid β-glycerophosphatase11 | |||
| Acid mucopolysaccharide292 | |||
| α1-Antitrypsin293 | |||
| α-Mannosidase11 | |||
| Azurocidin/CAP37/heparin binding protein294-296 | |||
| Bactericidal permeability increasing protein297 | |||
| β-Glycerophosphatase7 | |||
| β-Glucuronidase7 298 | |||
| Cathepsins11 | |||
| Defensins43 299 | |||
| Elastase300 | |||
| Lysozyme7,8 298 | |||
| Myeloperoxidase301 | |||
| N-Acetyl-β-glucosaminidase7 | |||
| Proteinase-3302 | |||
| Sialidase303 | |||
| Ubiquitin-protein304 | Matrix | ||
| β2-Microglobulin320 | |||
| Collagenase321 | |||
| Gelatinase21 322 | |||
| hCAP-18117 | |||
| Histaminase323 | |||
| Heparanase324 | |||
| Lactoferrin301 | |||
| Lysozyme7,8 298 | |||
| NGAL126 | |||
| Urokinase-type plasminogen activator319 325 | |||
| Sialidase303 | |||
| SGP2840 | |||
| Vitamin B12-binding protein326 | Matrix | ||
| Acetyltransferase332 | |||
| β2-Microglobulin20 | |||
| Gelatinase16,21 107 | |||
| Lysozyme45 | Matrix | ||
| Plasma proteins24 25 (including tetranectin) |
| Azurophil Granules . | Specific Granules . | Gelatinase Granules . | Secretory Vesicles . |
|---|---|---|---|
| Membrane | |||
| CD6359 289 | |||
| CD68290 | |||
| V-type H+-ATPase291 | Membrane | ||
| CD11b64,104 | |||
| CD15 antigens305 | |||
| CD66306 | |||
| CD67306 | |||
| Cytochrome b55817,52,105 | |||
| fMLP-R131,307 308 | |||
| Fibronectin-R309 | |||
| G-proteinα-subunit310 311 | |||
| Laminin-R309 | |||
| NB 1 antigen312 | |||
| 19-kD protein313 | |||
| 155-kD protein314 | |||
| Rap1, Rap2315,316 | |||
| SCAMP170 | |||
| Thrombospondin-R317 | |||
| TNF-R318 | |||
| Urokinase-type plasminogen activator-R319 | |||
| VAMP-2170 | |||
| Vitronectin-R309 | Membrane | ||
| CD11b64,109,327-330 | |||
| Cytochrome b55820 | |||
| Diacylglycerol-deacylating enzyme331 | |||
| fMLP-R109 131 | |||
| SCAMP170 | |||
| Urokinase-type plasminogen activator-R319 | |||
| VAMP-2170 | |||
| V-type H+-ATPase291 | Membrane | ||
| Alkaline phosphatase23-26 66 | |||
| CR165 | |||
| Cytochrome b55862,333 | |||
| CD11b62,64 | |||
| CD14334 | |||
| CD1663 334 * | |||
| fMLP-R131 | |||
| SCAMP170 | |||
| Urokinase-type plasminogen activator-R319 | |||
| V-type H+-ATPase291 | |||
| VAMP-2170 | |||
| CD10, CD13, CD45335 * | |||
| C1q-receptor336 * | |||
| DAF60 * | |||
| Matrix | |||
| Acid β-glycerophosphatase11 | |||
| Acid mucopolysaccharide292 | |||
| α1-Antitrypsin293 | |||
| α-Mannosidase11 | |||
| Azurocidin/CAP37/heparin binding protein294-296 | |||
| Bactericidal permeability increasing protein297 | |||
| β-Glycerophosphatase7 | |||
| β-Glucuronidase7 298 | |||
| Cathepsins11 | |||
| Defensins43 299 | |||
| Elastase300 | |||
| Lysozyme7,8 298 | |||
| Myeloperoxidase301 | |||
| N-Acetyl-β-glucosaminidase7 | |||
| Proteinase-3302 | |||
| Sialidase303 | |||
| Ubiquitin-protein304 | Matrix | ||
| β2-Microglobulin320 | |||
| Collagenase321 | |||
| Gelatinase21 322 | |||
| hCAP-18117 | |||
| Histaminase323 | |||
| Heparanase324 | |||
| Lactoferrin301 | |||
| Lysozyme7,8 298 | |||
| NGAL126 | |||
| Urokinase-type plasminogen activator319 325 | |||
| Sialidase303 | |||
| SGP2840 | |||
| Vitamin B12-binding protein326 | Matrix | ||
| Acetyltransferase332 | |||
| β2-Microglobulin20 | |||
| Gelatinase16,21 107 | |||
| Lysozyme45 | Matrix | ||
| Plasma proteins24 25 (including tetranectin) |
This localization is based on kinetics of upregulation in response to stimulation with inflammatory mediators, but has not yet been demonstrated by subcellular localization by immunocytochemistry.