Mean Measured Diameters (in mm) of the Inflamed Area After Injection With PBS, FMLP, LPS, RANTES, and MCP-1
| Treatment 50 μL . | Mean of Major Diameters of 4 Samples (mm) . | P< . |
|---|---|---|
| PBS (control) | ND | — |
| FMLP 10−6 mol/L | 37.16 ± 8 | .05 |
| LPS 10 ng | 84.66 ± 10 | — |
| RANTES 20 ng | 70.52 ± 12 | (*) |
| RANTES 10 ng | 58.45 ± 11 | (**) |
| RANTES 5 ng | 10 ± 10 | — |
| MCP-1 20 ng | 22.1 ± 5 | .01 |
| MCP-1 10 ng | 20.3 ± 5 | .01 |
| MCP-1 5 ng | ND | — |
| Treatment 50 μL . | Mean of Major Diameters of 4 Samples (mm) . | P< . |
|---|---|---|
| PBS (control) | ND | — |
| FMLP 10−6 mol/L | 37.16 ± 8 | .05 |
| LPS 10 ng | 84.66 ± 10 | — |
| RANTES 20 ng | 70.52 ± 12 | (*) |
| RANTES 10 ng | 58.45 ± 11 | (**) |
| RANTES 5 ng | 10 ± 10 | — |
| MCP-1 20 ng | 22.1 ± 5 | .01 |
| MCP-1 10 ng | 20.3 ± 5 | .01 |
| MCP-1 5 ng | ND | — |
These values represent the mean ± SD of the major diameters of inflamed injection sites in four separate experiments. Each animal received a 50 μL intradermal injection and then was killed after 4 hours. The P values (Student's t-test) are calculated by comparing RANTES (20-10 ng)-treated animals, respectively.
Abbreviation: ND, not determined.