Table 1. Frequency of p53, p21 Waf1 ,... | American Society of Hematology

Table 1.

Frequency of p53, p21^Waf1, and p16^INK4a Gene Alterations and Expression in MCLs

Diagnosis	p53 Mutations	p21^Waf1			p16^INK4a
MCL Variant		Deletions	Mutational Analysis	Loss of Expression	Deletions	Mutational Analysis	Loss of Expression
Aggressive	2/6	0/5	0/5	1/6	3/6^*	0/3^†	2/5
Typical	0/18	0/18	1/18^‡	0/18	0/18	1/18^‡	0/17

Total	2/24	0/23	1/23	1/24	3/24	1/21	2/22

Diagnosis	p53 Mutations	p21^Waf1			p16^INK4a
MCL Variant		Deletions	Mutational Analysis	Loss of Expression	Deletions	Mutational Analysis	Loss of Expression
Aggressive	2/6	0/5	0/5	1/6	3/6^*	0/3^†	2/5
Typical	0/18	0/18	1/18^‡	0/18	0/18	1/18^‡	0/17

Total	2/24	0/23	1/23	1/24	3/24	1/21	2/22

Two cases showed homozygous deletions by Southern blot analysis. One additional case had a hemizygous deletion of the 9p −del (9) (p12)−. No DNA was available in this case.

†

The SSCP analysis was not performed in the cases with homozygous p16^INK4a gene deletion.

‡

The two cases with anomalous SSCP had a known polymorphism in codons 31 of p21^Waf1 gene and codon 148 of p16^INK4a gene, respectively.

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