Multivariate analysis of the prognostic impact of clonal interference of signaling mutations on EFS and OS
| Risk factor . | EFS . | OS . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Signaling clones | ||||
| None | 1 | 1 | ||
| Single | 1.38 (0.84-2.29) | .21 | 1.01 (0.5-2.02) | .98 |
| Clonal interference | 2.44 (1.44-4.14) | .001 | 2.07 (1.03-4.15) | .04 |
| Log(WBC) | 1.26 (1.09-1.44) | .001 | 1.11 (0.92-1.33) | .27 |
| CBF type | .002 | .008 | ||
| inv(16) | 1 | 1 | ||
| t(8;21) | 1.69 (1.2-2.37) | 1.88 (1.18-2.98) | ||
| Age, y | 1.02 (1.01-1.03) | .001 | 1.03 (1.02-1.04) | <.0001 |
| Total VAF of signaling clones, % | 0.5 (0.16-1.53) | .22 | 0.58 (0.12-2.73) | .49 |
| Risk factor . | EFS . | OS . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Signaling clones | ||||
| None | 1 | 1 | ||
| Single | 1.38 (0.84-2.29) | .21 | 1.01 (0.5-2.02) | .98 |
| Clonal interference | 2.44 (1.44-4.14) | .001 | 2.07 (1.03-4.15) | .04 |
| Log(WBC) | 1.26 (1.09-1.44) | .001 | 1.11 (0.92-1.33) | .27 |
| CBF type | .002 | .008 | ||
| inv(16) | 1 | 1 | ||
| t(8;21) | 1.69 (1.2-2.37) | 1.88 (1.18-2.98) | ||
| Age, y | 1.02 (1.01-1.03) | .001 | 1.03 (1.02-1.04) | <.0001 |
| Total VAF of signaling clones, % | 0.5 (0.16-1.53) | .22 | 0.58 (0.12-2.73) | .49 |
All analyses are stratified on the HTS platform.