Clinical characteristics of patients according to the presence of clonal interference
| . | Signaling clones . | P* . | ||
|---|---|---|---|---|
| No . | Single . | Interference . | ||
| Cases, n (%) | 152 (34) | 167 (38) | 126 (28) | |
| Age, median (range), y | 43 (4-79) | 39 (1-80) | 43 (2-81) | .004 |
| Sex, n (%) | .69 | |||
| Male | 79 (52) | 100 (60) | 72 (58) | |
| Female | 73 (48) | 67 (40) | 54 (42) | |
| CBF type, n (%) | .025 | |||
| t(8;21) | 110 (72) | 77 (46) | 43 (34) | |
| inv(16) | 42 (28) | 90 (54) | 83 (66) | |
| WBC, median (range), × 109/L | 7.1 (1-252) | 22.5 (0.1-231) | 24.8 (0.1-351) | .24 |
| ACA, n (%) (n = 406) | .62† | |||
| Absent | 42 (29) | 74 (49) | 60 (55) | |
| Present | 102 (71) | 78 (51) | 50 (45) | |
| Induction outcome, n (%) | .68 | |||
| CR | 147 (96) | 158 (94) | 119 (94) | |
| Early death | 2 (2) | 8 (5) | 7 (6) | |
| Primary induction failure | 3 (2) | 1 (1) | 0 (0) | |
| MRD log reduction, median (IQR) | n = 44 | n = 45 | n = 53 | |
| After 1 course | 3.1 (2.6-3.7) | 2.7 (2.2-3.3) | 2.6 (2.2-3.2) | .89‡ |
| After 2 courses | 3.6 (2.9-4.6) | 3.2 (2.5-4.3) | 3.1 (2.7-3.8) | .77‡ |
| . | Signaling clones . | P* . | ||
|---|---|---|---|---|
| No . | Single . | Interference . | ||
| Cases, n (%) | 152 (34) | 167 (38) | 126 (28) | |
| Age, median (range), y | 43 (4-79) | 39 (1-80) | 43 (2-81) | .004 |
| Sex, n (%) | .69 | |||
| Male | 79 (52) | 100 (60) | 72 (58) | |
| Female | 73 (48) | 67 (40) | 54 (42) | |
| CBF type, n (%) | .025 | |||
| t(8;21) | 110 (72) | 77 (46) | 43 (34) | |
| inv(16) | 42 (28) | 90 (54) | 83 (66) | |
| WBC, median (range), × 109/L | 7.1 (1-252) | 22.5 (0.1-231) | 24.8 (0.1-351) | .24 |
| ACA, n (%) (n = 406) | .62† | |||
| Absent | 42 (29) | 74 (49) | 60 (55) | |
| Present | 102 (71) | 78 (51) | 50 (45) | |
| Induction outcome, n (%) | .68 | |||
| CR | 147 (96) | 158 (94) | 119 (94) | |
| Early death | 2 (2) | 8 (5) | 7 (6) | |
| Primary induction failure | 3 (2) | 1 (1) | 0 (0) | |
| MRD log reduction, median (IQR) | n = 44 | n = 45 | n = 53 | |
| After 1 course | 3.1 (2.6-3.7) | 2.7 (2.2-3.3) | 2.6 (2.2-3.2) | .89‡ |
| After 2 courses | 3.6 (2.9-4.6) | 3.2 (2.5-4.3) | 3.1 (2.7-3.8) | .77‡ |
P values from logistic or linear regressions adjusted on HTS platform comparing patients with a single clone vs clonal interference.
P values from linear regressions adjusted on CBF type.
P values from linear regressions adjusted on CBF type and induction arm (7+3 or intensified), according to Jourdan et al.20