Peripheral blood counts from 7- to 10-week-old Bak+/+Bax+/+, Bak−/−Baxfl/fl, and Bak−/−BaxPf4∆/Pf4∆ female and male mice
| . | Bak+/+Bax+/+(n = 11) . | Bak−/−Baxfl/fl (n = 16) . | Bak−/−BaxPf4∆/Pf4∆ (n = 14) . |
|---|---|---|---|
| Platelets, ×106/mL | 1201 ± 135 | 1844 ± 224*** | 2148 ± 192*** |
| MPV, femtoliters | 7.5 ± 0.3 | 7.8 ± 0.4 | 7.7 ± 0.3 |
| Hematocrit, % | 48.7 ± 2.7 | 51.0 ± 3.3 | 50.1 ± 4.6 |
| Erythrocytes, ×109/mL | 9.7 ± 0.6 | 10.2 ± 0.7 | 10.1 ± 0.9 |
| Leukocytes, ×106/mL | 7.5 ± 1.6 | 8.0 ± 1.4 | 8.3 ± 1.6 |
| Neutrophils, ×106/mL | 0.9 ± 0.6 | 0.8 ± 0.3 | 1.6 ± 1.6 |
| Lymphocytes, ×106/mL | 6.2 ± 1.8 | 6.8 ± 1.2 | 6.4 ± 2.2 |
| Monocytes, ×106/mL | 0.1 ± 0.1 | 0.1 ± 0.0 | 0.1 ± 0.1 |
| Eosinophils, ×106/mL | 0.1 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 |
| . | Bak+/+Bax+/+(n = 11) . | Bak−/−Baxfl/fl (n = 16) . | Bak−/−BaxPf4∆/Pf4∆ (n = 14) . |
|---|---|---|---|
| Platelets, ×106/mL | 1201 ± 135 | 1844 ± 224*** | 2148 ± 192*** |
| MPV, femtoliters | 7.5 ± 0.3 | 7.8 ± 0.4 | 7.7 ± 0.3 |
| Hematocrit, % | 48.7 ± 2.7 | 51.0 ± 3.3 | 50.1 ± 4.6 |
| Erythrocytes, ×109/mL | 9.7 ± 0.6 | 10.2 ± 0.7 | 10.1 ± 0.9 |
| Leukocytes, ×106/mL | 7.5 ± 1.6 | 8.0 ± 1.4 | 8.3 ± 1.6 |
| Neutrophils, ×106/mL | 0.9 ± 0.6 | 0.8 ± 0.3 | 1.6 ± 1.6 |
| Lymphocytes, ×106/mL | 6.2 ± 1.8 | 6.8 ± 1.2 | 6.4 ± 2.2 |
| Monocytes, ×106/mL | 0.1 ± 0.1 | 0.1 ± 0.0 | 0.1 ± 0.1 |
| Eosinophils, ×106/mL | 0.1 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 |
Data represent mean ± SD, 1-way ANOVA with Dunnett’s multiple comparison test. Data are compared with Bak+/+Bax+/+ (wild type).
MPV, mean platelet volume.
P < .001.