Effects of IL-11 on Cytoablative Preclinical Models
| Models . | Peripheral Blood . | Bone Marrow . | Spleen . | Thymus . | GI Tract . | Other . |
|---|---|---|---|---|---|---|
| BMT122-127 | WBC↑, N↑ | CFU-mix↑ | CFU-mix | Myeloid leukemia | ||
| Plt↑ | CFU-GM↑ | CFU-GM↑ | Body weight↓ | |||
| Reticulocyte↑ | CFU-MK↑ | CFU-MK↑ | Hyperactive state | |||
| Pseudomonas aeruginosa LD50↑ | Cellularity↑ | Cellularity↑ | Thymic atrophy | |||
| Tail bleeding time↓ | Inflammation | |||||
| Acute-phase protein↑ | ||||||
| Sublethal122 128 | WBC↑ | Cellularity↑ | Cellularity↑ | Pneumonitis | ||
| Plt↑ | T- & B-cell function | T- & B-cell function↑ | ||||
| Chemotherapy42,66 129-133 | WBC↑, N↑ Plt↑ | Cellularity↑ | tCellularity↑ | ↓Frequency, severity and duration of oral mucositis | ↑Survival | |
| Hct↑ | CFU-mix↑ | SRBC-specific plaque | ||||
| Pancytopenia↓ | CFU-GM↑ | Forming cells↑ | ||||
| SRBC-specific Ab↑ | BFU-E↑ | CFU-mix, GM, BFU-E↑ | ||||
| Chemoradiation therapy79 134 | Late recovery of Plt & Hct | BFU-E↑ | BFU-E, CFU-GM & CFU-MK↑ at day 15 postirradiation | ↑Mitotic index & PCNA+ cells in crypts | ↑Recovery of spermatogenesis | |
| Mild ↑Plt at early stage postirradiation | CFU-GM↑ | ↓Apoptosis | ↑Survival | |||
| CFU-MK↑ | ||||||
| at day 15 & 30 postirradiation |
| Models . | Peripheral Blood . | Bone Marrow . | Spleen . | Thymus . | GI Tract . | Other . |
|---|---|---|---|---|---|---|
| BMT122-127 | WBC↑, N↑ | CFU-mix↑ | CFU-mix | Myeloid leukemia | ||
| Plt↑ | CFU-GM↑ | CFU-GM↑ | Body weight↓ | |||
| Reticulocyte↑ | CFU-MK↑ | CFU-MK↑ | Hyperactive state | |||
| Pseudomonas aeruginosa LD50↑ | Cellularity↑ | Cellularity↑ | Thymic atrophy | |||
| Tail bleeding time↓ | Inflammation | |||||
| Acute-phase protein↑ | ||||||
| Sublethal122 128 | WBC↑ | Cellularity↑ | Cellularity↑ | Pneumonitis | ||
| Plt↑ | T- & B-cell function | T- & B-cell function↑ | ||||
| Chemotherapy42,66 129-133 | WBC↑, N↑ Plt↑ | Cellularity↑ | tCellularity↑ | ↓Frequency, severity and duration of oral mucositis | ↑Survival | |
| Hct↑ | CFU-mix↑ | SRBC-specific plaque | ||||
| Pancytopenia↓ | CFU-GM↑ | Forming cells↑ | ||||
| SRBC-specific Ab↑ | BFU-E↑ | CFU-mix, GM, BFU-E↑ | ||||
| Chemoradiation therapy79 134 | Late recovery of Plt & Hct | BFU-E↑ | BFU-E, CFU-GM & CFU-MK↑ at day 15 postirradiation | ↑Mitotic index & PCNA+ cells in crypts | ↑Recovery of spermatogenesis | |
| Mild ↑Plt at early stage postirradiation | CFU-GM↑ | ↓Apoptosis | ↑Survival | |||
| CFU-MK↑ | ||||||
| at day 15 & 30 postirradiation |
Abbreviations: CFU-mix, colony-forming unit-mix; CFU-GM, colony-forming unit-granulocyte/macrophage; CFU-MK, colony-forming unit-megakaryocyte; WBC, white blood cells; N, neutrophils; Plt, platelets; Hct, hematocrit; SRBC, sheep red blood cell; PCNA, proliferating cell nuclear antigen.