Apo(a) and Defensin in Cerebral Arteries: Individuals With Prior Clinical Evidence of Atherosclerosis
| Patient No. . | Age (yr)/Sex . | Race . | AS Risks . | Clinical AS . | Systemic AS . | CAS . | CApo(a) . | DEF . |
|---|---|---|---|---|---|---|---|---|
| 22 | 74/M | C | HTN | PVD | CA-min | 3 | +++ | +++ |
| Aorta-severe | ||||||||
| 23 | 59/M | AA | HTN, lipids | CAD, MI | CA-severe | 4 | ++ | ++ |
| Aorta-mod | ||||||||
| 24 | 70/M | C | cig, XRT | CAD, MI, CI | CA-severe | 4 | ++ | ++ |
| Aorta-mod | ||||||||
| 25 | 62/F | C | HTN, lipids, cig | MI, PVD | CA-mod | 3 | ++ | ++ |
| Aorta-severe | ||||||||
| 26 | 51/M | AA | HTN | MI | CA-severe | 3 | ++ | ++ |
| Aorta-mod | ||||||||
| 27 | 73/M | unk | CS, MI | CA-severe | 1 | + | ++ | |
| Aorta-mild | ||||||||
| 28 | 71/M | C | DM, HTN, | PVD, CAD, CS | CA-severe | 0 | + | + |
| Aorta-severe |
| Patient No. . | Age (yr)/Sex . | Race . | AS Risks . | Clinical AS . | Systemic AS . | CAS . | CApo(a) . | DEF . |
|---|---|---|---|---|---|---|---|---|
| 22 | 74/M | C | HTN | PVD | CA-min | 3 | +++ | +++ |
| Aorta-severe | ||||||||
| 23 | 59/M | AA | HTN, lipids | CAD, MI | CA-severe | 4 | ++ | ++ |
| Aorta-mod | ||||||||
| 24 | 70/M | C | cig, XRT | CAD, MI, CI | CA-severe | 4 | ++ | ++ |
| Aorta-mod | ||||||||
| 25 | 62/F | C | HTN, lipids, cig | MI, PVD | CA-mod | 3 | ++ | ++ |
| Aorta-severe | ||||||||
| 26 | 51/M | AA | HTN | MI | CA-severe | 3 | ++ | ++ |
| Aorta-mod | ||||||||
| 27 | 73/M | unk | CS, MI | CA-severe | 1 | + | ++ | |
| Aorta-mild | ||||||||
| 28 | 71/M | C | DM, HTN, | PVD, CAD, CS | CA-severe | 0 | + | + |
| Aorta-severe |
Abbreviations: C, Caucasian; A, Asian; AA, African-American; unk, unknown race; DM, diabetes mellitus; HTN, hypertension; cig, cigarette use; lipids, lipid disorder of any type; XRT, whole brain irradiation; MI, myocardial infarction; CI, ischemic cerebral infarction; CS, carotid stenosis; PVD, peripheral vascular disease; CA, coronary arteries; CAD, coronary artery disease; CApo(a), immunohistochemical deposition of cerebral apolipoprotein (a); −, no staining; +, focal rare endothelial cell staining in an atherosclerotic plaque or normal appearing vessel wall; ++, focal subendothelial cell staining ± endothelial staining in an atherosclerotic plaque; +++, diffuse extensive subendothelial cell staining in an atherosclerotic plaque; DEF, immunohistochemical deposition of defensin.