Exposure to Miscellaneous Drugs in Days 29-180 Before Admission Among 253 Subjects With Aplastic Anemia and 1,174 Controls
| Drug . | Subjects: No. (%) . | Controls: No. (%) . | Crude Relative Risk . | Multivariate Relative Risk (95% confidence interval) . |
|---|---|---|---|---|
| Thiazides | 6 (2) | 5 (0.4) | 5.7 | 7.7 (1.5-40) |
| Mebendazole | 4 (2) | 3 (0.3) | 6.33-150 | — |
| Benzodiazepines | 9 (4) | 18 (2) | 2.4 | 1.3 (0.5-3.5) |
| Other psychoactive drugs3-151 | 8 (3) | 25 (2) | — | — |
| Chlorpheniramine | 50 (20) | 265 (23) | 0.8 | 0.5 (0.2-1.2) |
| Other antihistamines3-152 | 6 (2) | 42 (4) | — | — |
| Phenylpropanolamine | 43 (17) | 221 (19) | 0.9 | 1.8 (0.7-4.7) |
| Unspecified cold/fever drug | 42 (17) | 162 (14) | — | — |
| Diphenoxylate/atropine | 15 (6) | 41 (3) | 1.7 | 1.7 (0.9-3.4) |
| Loperamide | 3 (1) | 6 (0.5) | — | — |
| Unspecified antidiarrheal | 10 (4) | 27 (2) | — | — |
| Oral contraceptives | 6 (2) | 31 (3) | 0.9 | 0.6 (0.2-1.7) |
| Herbal preparationsρ | 58 (23) | 218 (19) | — | — |
| Drug . | Subjects: No. (%) . | Controls: No. (%) . | Crude Relative Risk . | Multivariate Relative Risk (95% confidence interval) . |
|---|---|---|---|---|
| Thiazides | 6 (2) | 5 (0.4) | 5.7 | 7.7 (1.5-40) |
| Mebendazole | 4 (2) | 3 (0.3) | 6.33-150 | — |
| Benzodiazepines | 9 (4) | 18 (2) | 2.4 | 1.3 (0.5-3.5) |
| Other psychoactive drugs3-151 | 8 (3) | 25 (2) | — | — |
| Chlorpheniramine | 50 (20) | 265 (23) | 0.8 | 0.5 (0.2-1.2) |
| Other antihistamines3-152 | 6 (2) | 42 (4) | — | — |
| Phenylpropanolamine | 43 (17) | 221 (19) | 0.9 | 1.8 (0.7-4.7) |
| Unspecified cold/fever drug | 42 (17) | 162 (14) | — | — |
| Diphenoxylate/atropine | 15 (6) | 41 (3) | 1.7 | 1.7 (0.9-3.4) |
| Loperamide | 3 (1) | 6 (0.5) | — | — |
| Unspecified antidiarrheal | 10 (4) | 27 (2) | — | — |
| Oral contraceptives | 6 (2) | 31 (3) | 0.9 | 0.6 (0.2-1.7) |
| Herbal preparationsρ | 58 (23) | 218 (19) | — | — |
P = .03.
Includes amitriptyline (1 subject, 1 control), amitriptyline and unspecified tranquilizer (1, 0), mianserin (1, 0), haloperidol (1, 0), metoclopramide (0, 2), unspecified sedative/tranquilizer (4, 22).
Includes triprolidine (2 subjects, 6 controls), clemizole (1, 10), diphenhydramine (1, 1), doxylamine (1, 0), cinarrazin (0, 5), hydroxyzine (0, 5), dimenhydrinate (0, 4), cinarrazin and dimenhydrinate (0, 1), astemizol (0, 1), flunarazine (0, 1), mebhydrolin (0, 1), mebhydrolin (0, 1), unspecified antihistamine (1, 7).
ρ The preparations taken by 14 subjects (6%) and 75 controls (6%) included both herbal ingredients and drugs.