Exposure to Analgesics and NSAIDs in Days 29-180 Before Admission Among 253 Subjects With Aplastic Anemia and 1,174 Controls
| Drug . | Subjects: No. (%) . | Controls: No. (%) . | Crude Relative Risk . | Multivariate Relative Risk (95% confidence interval) . |
|---|---|---|---|---|
| Salicylates | ||||
| <4 d/wk | 47 (19) | 193 (16) | 1.2 | 0.9 (0.6-1.4) |
| ≥4 d/wk | 7 (3) | 32 (3) | 1.0 | 1.0 (0.4-2.4) |
| Paracetamol | ||||
| <4 d/wk | 97 (38) | 455 (39) | 1.0 | 1.2 (0.8-1.7) |
| ≥4 d/wk | 18 (7) | 65 (6) | 1.3 | 1.3 (0.7-2.5) |
| Pyrazolones* | 5 (2) | 32 (3) | 0.7 | 0.5 (0.2-1.6) |
| NSAIDs† | 5 (2) | 12 (1) | — | — |
| Unspecified pain medication | 21 (8) | 105 (9) | — | — |
| Drug . | Subjects: No. (%) . | Controls: No. (%) . | Crude Relative Risk . | Multivariate Relative Risk (95% confidence interval) . |
|---|---|---|---|---|
| Salicylates | ||||
| <4 d/wk | 47 (19) | 193 (16) | 1.2 | 0.9 (0.6-1.4) |
| ≥4 d/wk | 7 (3) | 32 (3) | 1.0 | 1.0 (0.4-2.4) |
| Paracetamol | ||||
| <4 d/wk | 97 (38) | 455 (39) | 1.0 | 1.2 (0.8-1.7) |
| ≥4 d/wk | 18 (7) | 65 (6) | 1.3 | 1.3 (0.7-2.5) |
| Pyrazolones* | 5 (2) | 32 (3) | 0.7 | 0.5 (0.2-1.6) |
| NSAIDs† | 5 (2) | 12 (1) | — | — |
| Unspecified pain medication | 21 (8) | 105 (9) | — | — |
Includes dipyrone (3 subjects, 25 controls); propyphenazone (2, 2); aminopyrine (0, 2); dipyrone and aminopyrine (0, 1); dipyrone and propyphenazone (0, 1); antipyrine (0, 1).
Includes diclofenac (1 subject, 3 controls), piroxicam (1, 3), mefanamic acid (1, 2), naproxen (1, 1), indomethacin (1, 1), phenylbutazone (0, 2).