Table 1.

Exposure to Systemic Antibiotics in Days 29-180 Before Admission Among 253 Subjects With Aplastic Anemia and 1,174 Controls

DrugSubjects: No. (%)Controls: No. (%)Crude Relative RiskMultivariate Relative Risk (95% confidence interval)
Chloramphenicol 4 (2) 8 (1)  2.3 2.7 (0.7-10)  
Sulfonamides 5 (2) 3 (0.3) 7.9*  —  
Tetracyclines 5 (2) 13 (1)  1.8 1.8 (0.6-5.6) 
Penicillins 6 (2) 25 (2)  1.1 1.0 (0.4-2.7) 
Ampicillin/amoxicillin 13 (5) 48 (4)  1.3 1.3 (0.6-2.8) 
Other named antibiotics 2 (1) 9 (1)   —   —  
Unspecified antibiotic 23 (9) 71 (6)   —   —  
DrugSubjects: No. (%)Controls: No. (%)Crude Relative RiskMultivariate Relative Risk (95% confidence interval)
Chloramphenicol 4 (2) 8 (1)  2.3 2.7 (0.7-10)  
Sulfonamides 5 (2) 3 (0.3) 7.9*  —  
Tetracyclines 5 (2) 13 (1)  1.8 1.8 (0.6-5.6) 
Penicillins 6 (2) 25 (2)  1.1 1.0 (0.4-2.7) 
Ampicillin/amoxicillin 13 (5) 48 (4)  1.3 1.3 (0.6-2.8) 
Other named antibiotics 2 (1) 9 (1)   —   —  
Unspecified antibiotic 23 (9) 71 (6)   —   —  
*

P = .004.

Includes cloxacillin (1 subject, 3 controls), norfloxacin and metronidazole (1, 0), norfloxacin (0, 2), dicloxacillin (0, 2), erythromycin (0, 2).

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