Sequences of Recombinations Between c-myc and Ig Loci
| BALB/cAn, day 0 . | C.D2-Idh1-Pep-3, day 0 . |
|---|---|
| GCCCAGCTAAGCCCAAACTA GTTCCGTAACAGCTGCTACC NO α | TCACCCCAGCTCAGCTCAGC TTGAAGGCTGGATTTCCTTT PP μ |
| AGCTCAGCTCAGCTCAGCTC GGCTAGCGCAGTGAGGAGAA SP μ | CTCATCCCAGCTCATTCCAG CTCGAGCTGTTTGAAGGCTG PP α |
| TTTAGCTCAGCTCAGCCTAG GGTGGTCTTTCCCTGTGTTC PP α | GCTCACCCTAGCTCAGCTCA GCCGGTTGGACATTCTTGCT NO μ |
| TCCCAGCTCATTCCAGGTCA TGGAGAAGGGATTACCTTTT PP α | GCTCACCCCAGCTCAGCTCA GTTCCCGAGGTTACTATGGG NO μ |
| CCCAGCTCAGCTCACCCCAC CTTCTGACTTACCAGTCTCT PP μ | GTTCAACCCACCAGCTCACA GAGAGGGCATTTAAATTTCA NO α |
| AGTTTAGCTAGTCCAGTCCA CTTCTGACTTACCAGTCTCT GU α | AGCCCAGCTCACCCCAGCTC AGTTGGGGTAGGCTGGGGTA PP μ |
| CCAGCTTACCCCAACTCACC TTGCGTTTGGGAGCGAGAAG GU μ/α | CCCCATCTCAGCTACTCCAG AGTAAGCACAGATCTGGTGG PP μ |
| CTAGCTTACCCCAACTCACC TTGCGTTTGGGAGCGAGAAG GU μ | DBA/2N, day 0 |
| TCCATTCTAGCCTAGCCCAG ACCAGTCTCTGAGAGGGCAT GU α | ACTCCAGCCCAGCTCAGCTC CATTTCTGACAGCCTGGGAC SP μ |
| CCTAGCCCAGACCATGCCAG TTGACACTTTTCTCAAGAGT GU α | AGCCCAGCCCAACTCACCCA TCTGCCTCTGCCCGCGATCA NO ? |
| CACACCAGCCCAGTCCAGCC TAGTTGGGGTAGGCTGGGGT GU α | |
| TCACACCAGCCAGCCCAGCC TCTGGTGGTCTTTCCCTGTG GU α | |
| BALB/cAn, day 7 | C.D2-Igh1c, day 7 |
| TCTCAGCCAAGCTTAGCTCA GACACGGAGGTCGTCCCGCC OG α | AGTATTAGGGACCAGTCCTT AGGGGCTTTCTTTCCGAGCC PP γ2B /α |
| AGCCTAGCTCAGCTCAGCTC ATCTGCGAGCCAGGACAGGA OG μ | ATCCCAGCTCATTCCAGCTC ATCCTGAGGTCTTTGGAGAA LN α |
| GGGAGTATTAGGGACCAGTC CTTCTGACTTACCAGTCTCT OG γ2B /α | CCTATTCCAGCCTAGCTTAG TTTTCTCAAGAGTAGTTGGG LN α |
| CCCAGTTCAGCTCACCCCAG CTTGTCAAGATGACAGAGGA SP μ | CCAGCTCATTCCAGCTCAGC CAGGACTCCCCAGGCTCCGG PP α |
| ACCCAGCTCAGCTCAGCTCA GCTTTCTTACATTAATTGAT PP/LN μ | TCACCCCAGCTCACCCCAGC TGTTATTTCTGCGTCTTGAA PP μ |
| TCAGATCAGCTCACCCCAAC ACAGCCTGGGACCGACACGG SP μ | CAGCCCATCCCAGATCAATC TGGAAACCCCAGTAAGTACA LN ?/α |
| CAGCCCAGCCCAACCTATTC CAGCCTGGGACCGACACGGA SP α | TCACCCCAGCTCAGCCCAGA CGCCCACTCTCCCCAACCCT PP μ |
| CAGCCTAGCTCAGCTCATCC TAGATCTGAGTCGGGGTAGA OG α | CTCAGCCTAACCCAGCTCAC AAACCCCAGTAAGCACAGAT PP α |
| CTAGCTAAGCCCAGCTCAGC TACCAGTCTCTGAGAGGGCA PP ? | TCAGTTTATTCCAGTCTAGT TAGCTTCTGACTTACCAGTC PP ?/α |
| TCATTCATATCCAGAGCATC GCTACATTAATTGATATGTG PP α | ATTCCAGCTCAGCACAACCC GTTGGCTAGCGCAGTGAGGA OG α |
| TATTCCATCTCATTCCAGCT CAGTCTTTCTTCCATTCCTG OG/SP α | TCCATCCAGCCTTGCTCACT TTTGCTACATTAATTGATAT PP α |
| TCAGCTCAGCCTAGCCCAGC TCTGCGTCTTGAATGTAGCG PP α | C57BL/6, day 7 |
| CTAGCTCAGCCCATTCCAGC TCTGAGTCGGGGTAGAGCGA SP α | AGCTCAGCTCAGCTCACCCC AGCTTCTGACTTACCAGTCT PP μ |
| ATCTCATTCCAGCTCAGCTC TCTGAGTCGGGGTAGAGCGA SP α | ACACCAGCCAGCCCAGCTCA TTTGTCTATTTGGGGACAGT GU ? |
| CCAGCCCAGCCTTTTCCAGG CTTTTAAGAAGTTGCTATTT PP α | CCCCAGCTCAGCTCAGCTCA CTCCGTAGCTTCTGACTTAC GU μ |
| CAATCTGGTTCAGCCCAGAC CAGCCTGGGACCGACACGGA OG ε/α | DBA/2N, day 7 |
| GCTCATTCCAGCTCAGCTCA CAGTCTCTGAGAGGGCATTT SP α | CATCCCAGCTTACCCCAGCT CAGCCTGGGACCGACACGGA PP μ |
| ATTCCAGCTCAGCACAACCC GTTGGCTAGCGCAGTGAGGA PP α | GCTCAGTCCAGCTCAGCCCA GCTTTTGACACTTTTCTCAA PP μ |
| GCCTAACCCAGCTAACACTA TGTTACATTAATTGATATGT OG α | CTCATATCAGCTCAGAACAG TTCTGACTTAACAGTCTCTG PP μ |
| CCAGTGTAGGCAGTAGAGTT ACGGTGACCCGGCCGGTTGG OG μ | ATAGCTGAGCTCACCCCAGC TAGGCTGGGGTAGATCTGAG PP μ |
| CCAGCCTAGCTCAGCTCAAA AGGCTGGGGTAGATCTGAGT PP α | TAGCCCAGCTCACACTATGT TACATTAATTGATATGTGTC PP ?/α |
| AGCTCAGCTCACCCCAGCTC AGAAAGCCCTTGGAATCCTG PP μ | GTCCAGCTCAGCCCAGCTCC ACAGAGGAAAGGGGAAGGGA PP μ |
| CAGCTCACACCAGCCCAGCC CAAGAGTAGTTGGGGTAGGC PP α | GCTCATCCCAGCTCATTCCA CTGACGCTGACCCGGCCGGT GU α |
| CACTCCAGCTCAGCTCAGCC CAGTCTCTGAGAGGGCATTT LN μ | C3H/HeJ, day 7 |
| AGCTCAGCCTAGCCCAGCTC CCTTTGGGCGTTGGAAACCC OG α | TCCAGCTCATCCCAGCCTGG TTTTGACACTTTTCTCAAGA PP α |
| CCTATTCCAGCCTAGCTCAG CTTTCTGCGTCTTGAATGTA SP α | AGCTCACCCCAACTCGGCTC GTAGCGGCCGGTTAGGACAG LN μ |
| CATCCTAGCTCATTCCAGCT CCAGTCTCTGAGAGGGCATT GU α | GTTTATCCTAGTCCATCGCA GCTTTGCTACATTAATTGAT PP α |
| CCTATTCCAGCCTAGCTCAG CTTGGAATCCTGAGGTCTTT GU α | GCCTATCCAGCCTAGCCCAG TATGTGTCCTTTGAGGGGTC GU α |
| TGTCCAGCTCTGCTCAGCCC ATATGTGTCCTTTGAGGGGT GU α | AGCCCAGCCCAGCCCTGGTT GGGCATTTAAATTTCAGCTT GU ?/α |
| AGCTCGCACCAGCCCAGCCC GTGTTCTTTCTGCGTCTTGA GU α | CAGCCTAGCTCTGCTCATCA GCCTCTGCCCGCGATCAGCT GU α |
| TCAGCTCAGCTCAGCTCAGC TCTGAGTCGGGGTAGAGCGA GU α | CTCTCCTCTCCTCTCCTCTC CTACTTGGGGACAGTGTTCT GU α |
| AGCTCACCCCAGCTCAGCTC AGTTGGGGTAGGCTGGGGTA GU μ | AGCCTATTCCAGCCTAGCTA ATGGGCTGACGTGACCCGGC PP/OG α |
| CCCCAGCTCAGCTCACCCCA GGGTCAAACCGGGAGGTCGC GU μ | |
| TATCCCAGCTCAGCACATCC TGGCTAGCGCAGTGAGGAGA GU α | |
| TCCTCTCCTCTCCTCTCCTT CCAGTCTCTGAGAGGGCATT GU α | |
| AACACAGCCCAGCCCAGCTC CCTTTGAGGGGTCAAACCGG GU ? | |
| ATTTTAGAAACGCTCAGAGA AGCTTGGTGCATTTCTGACA GU μ | |
| TCCCAGCTCATTCCAGGTCA TTGGAGAAGGGATTACCTTT SP α | |
| CTCCTAGCTGTTAGGTCTGG TCCTGAAAAGAGCTCCTCGA GU γ2B /α | |
| TAGCACACACCAGCCCAGCC CAGTGAGGAGAAGCAAAATT GU α | |
| CCCAGCCCAACCTATTCCAG CCCTCGGCGGGGAGAGGGAA GU α | |
| TCCAGCTCAGCCCAGCCTAA CCCGCGATCAGCTCTCCTGA LN/SP α |
| BALB/cAn, day 0 . | C.D2-Idh1-Pep-3, day 0 . |
|---|---|
| GCCCAGCTAAGCCCAAACTA GTTCCGTAACAGCTGCTACC NO α | TCACCCCAGCTCAGCTCAGC TTGAAGGCTGGATTTCCTTT PP μ |
| AGCTCAGCTCAGCTCAGCTC GGCTAGCGCAGTGAGGAGAA SP μ | CTCATCCCAGCTCATTCCAG CTCGAGCTGTTTGAAGGCTG PP α |
| TTTAGCTCAGCTCAGCCTAG GGTGGTCTTTCCCTGTGTTC PP α | GCTCACCCTAGCTCAGCTCA GCCGGTTGGACATTCTTGCT NO μ |
| TCCCAGCTCATTCCAGGTCA TGGAGAAGGGATTACCTTTT PP α | GCTCACCCCAGCTCAGCTCA GTTCCCGAGGTTACTATGGG NO μ |
| CCCAGCTCAGCTCACCCCAC CTTCTGACTTACCAGTCTCT PP μ | GTTCAACCCACCAGCTCACA GAGAGGGCATTTAAATTTCA NO α |
| AGTTTAGCTAGTCCAGTCCA CTTCTGACTTACCAGTCTCT GU α | AGCCCAGCTCACCCCAGCTC AGTTGGGGTAGGCTGGGGTA PP μ |
| CCAGCTTACCCCAACTCACC TTGCGTTTGGGAGCGAGAAG GU μ/α | CCCCATCTCAGCTACTCCAG AGTAAGCACAGATCTGGTGG PP μ |
| CTAGCTTACCCCAACTCACC TTGCGTTTGGGAGCGAGAAG GU μ | DBA/2N, day 0 |
| TCCATTCTAGCCTAGCCCAG ACCAGTCTCTGAGAGGGCAT GU α | ACTCCAGCCCAGCTCAGCTC CATTTCTGACAGCCTGGGAC SP μ |
| CCTAGCCCAGACCATGCCAG TTGACACTTTTCTCAAGAGT GU α | AGCCCAGCCCAACTCACCCA TCTGCCTCTGCCCGCGATCA NO ? |
| CACACCAGCCCAGTCCAGCC TAGTTGGGGTAGGCTGGGGT GU α | |
| TCACACCAGCCAGCCCAGCC TCTGGTGGTCTTTCCCTGTG GU α | |
| BALB/cAn, day 7 | C.D2-Igh1c, day 7 |
| TCTCAGCCAAGCTTAGCTCA GACACGGAGGTCGTCCCGCC OG α | AGTATTAGGGACCAGTCCTT AGGGGCTTTCTTTCCGAGCC PP γ2B /α |
| AGCCTAGCTCAGCTCAGCTC ATCTGCGAGCCAGGACAGGA OG μ | ATCCCAGCTCATTCCAGCTC ATCCTGAGGTCTTTGGAGAA LN α |
| GGGAGTATTAGGGACCAGTC CTTCTGACTTACCAGTCTCT OG γ2B /α | CCTATTCCAGCCTAGCTTAG TTTTCTCAAGAGTAGTTGGG LN α |
| CCCAGTTCAGCTCACCCCAG CTTGTCAAGATGACAGAGGA SP μ | CCAGCTCATTCCAGCTCAGC CAGGACTCCCCAGGCTCCGG PP α |
| ACCCAGCTCAGCTCAGCTCA GCTTTCTTACATTAATTGAT PP/LN μ | TCACCCCAGCTCACCCCAGC TGTTATTTCTGCGTCTTGAA PP μ |
| TCAGATCAGCTCACCCCAAC ACAGCCTGGGACCGACACGG SP μ | CAGCCCATCCCAGATCAATC TGGAAACCCCAGTAAGTACA LN ?/α |
| CAGCCCAGCCCAACCTATTC CAGCCTGGGACCGACACGGA SP α | TCACCCCAGCTCAGCCCAGA CGCCCACTCTCCCCAACCCT PP μ |
| CAGCCTAGCTCAGCTCATCC TAGATCTGAGTCGGGGTAGA OG α | CTCAGCCTAACCCAGCTCAC AAACCCCAGTAAGCACAGAT PP α |
| CTAGCTAAGCCCAGCTCAGC TACCAGTCTCTGAGAGGGCA PP ? | TCAGTTTATTCCAGTCTAGT TAGCTTCTGACTTACCAGTC PP ?/α |
| TCATTCATATCCAGAGCATC GCTACATTAATTGATATGTG PP α | ATTCCAGCTCAGCACAACCC GTTGGCTAGCGCAGTGAGGA OG α |
| TATTCCATCTCATTCCAGCT CAGTCTTTCTTCCATTCCTG OG/SP α | TCCATCCAGCCTTGCTCACT TTTGCTACATTAATTGATAT PP α |
| TCAGCTCAGCCTAGCCCAGC TCTGCGTCTTGAATGTAGCG PP α | C57BL/6, day 7 |
| CTAGCTCAGCCCATTCCAGC TCTGAGTCGGGGTAGAGCGA SP α | AGCTCAGCTCAGCTCACCCC AGCTTCTGACTTACCAGTCT PP μ |
| ATCTCATTCCAGCTCAGCTC TCTGAGTCGGGGTAGAGCGA SP α | ACACCAGCCAGCCCAGCTCA TTTGTCTATTTGGGGACAGT GU ? |
| CCAGCCCAGCCTTTTCCAGG CTTTTAAGAAGTTGCTATTT PP α | CCCCAGCTCAGCTCAGCTCA CTCCGTAGCTTCTGACTTAC GU μ |
| CAATCTGGTTCAGCCCAGAC CAGCCTGGGACCGACACGGA OG ε/α | DBA/2N, day 7 |
| GCTCATTCCAGCTCAGCTCA CAGTCTCTGAGAGGGCATTT SP α | CATCCCAGCTTACCCCAGCT CAGCCTGGGACCGACACGGA PP μ |
| ATTCCAGCTCAGCACAACCC GTTGGCTAGCGCAGTGAGGA PP α | GCTCAGTCCAGCTCAGCCCA GCTTTTGACACTTTTCTCAA PP μ |
| GCCTAACCCAGCTAACACTA TGTTACATTAATTGATATGT OG α | CTCATATCAGCTCAGAACAG TTCTGACTTAACAGTCTCTG PP μ |
| CCAGTGTAGGCAGTAGAGTT ACGGTGACCCGGCCGGTTGG OG μ | ATAGCTGAGCTCACCCCAGC TAGGCTGGGGTAGATCTGAG PP μ |
| CCAGCCTAGCTCAGCTCAAA AGGCTGGGGTAGATCTGAGT PP α | TAGCCCAGCTCACACTATGT TACATTAATTGATATGTGTC PP ?/α |
| AGCTCAGCTCACCCCAGCTC AGAAAGCCCTTGGAATCCTG PP μ | GTCCAGCTCAGCCCAGCTCC ACAGAGGAAAGGGGAAGGGA PP μ |
| CAGCTCACACCAGCCCAGCC CAAGAGTAGTTGGGGTAGGC PP α | GCTCATCCCAGCTCATTCCA CTGACGCTGACCCGGCCGGT GU α |
| CACTCCAGCTCAGCTCAGCC CAGTCTCTGAGAGGGCATTT LN μ | C3H/HeJ, day 7 |
| AGCTCAGCCTAGCCCAGCTC CCTTTGGGCGTTGGAAACCC OG α | TCCAGCTCATCCCAGCCTGG TTTTGACACTTTTCTCAAGA PP α |
| CCTATTCCAGCCTAGCTCAG CTTTCTGCGTCTTGAATGTA SP α | AGCTCACCCCAACTCGGCTC GTAGCGGCCGGTTAGGACAG LN μ |
| CATCCTAGCTCATTCCAGCT CCAGTCTCTGAGAGGGCATT GU α | GTTTATCCTAGTCCATCGCA GCTTTGCTACATTAATTGAT PP α |
| CCTATTCCAGCCTAGCTCAG CTTGGAATCCTGAGGTCTTT GU α | GCCTATCCAGCCTAGCCCAG TATGTGTCCTTTGAGGGGTC GU α |
| TGTCCAGCTCTGCTCAGCCC ATATGTGTCCTTTGAGGGGT GU α | AGCCCAGCCCAGCCCTGGTT GGGCATTTAAATTTCAGCTT GU ?/α |
| AGCTCGCACCAGCCCAGCCC GTGTTCTTTCTGCGTCTTGA GU α | CAGCCTAGCTCTGCTCATCA GCCTCTGCCCGCGATCAGCT GU α |
| TCAGCTCAGCTCAGCTCAGC TCTGAGTCGGGGTAGAGCGA GU α | CTCTCCTCTCCTCTCCTCTC CTACTTGGGGACAGTGTTCT GU α |
| AGCTCACCCCAGCTCAGCTC AGTTGGGGTAGGCTGGGGTA GU μ | AGCCTATTCCAGCCTAGCTA ATGGGCTGACGTGACCCGGC PP/OG α |
| CCCCAGCTCAGCTCACCCCA GGGTCAAACCGGGAGGTCGC GU μ | |
| TATCCCAGCTCAGCACATCC TGGCTAGCGCAGTGAGGAGA GU α | |
| TCCTCTCCTCTCCTCTCCTT CCAGTCTCTGAGAGGGCATT GU α | |
| AACACAGCCCAGCCCAGCTC CCTTTGAGGGGTCAAACCGG GU ? | |
| ATTTTAGAAACGCTCAGAGA AGCTTGGTGCATTTCTGACA GU μ | |
| TCCCAGCTCATTCCAGGTCA TTGGAGAAGGGATTACCTTT SP α | |
| CTCCTAGCTGTTAGGTCTGG TCCTGAAAAGAGCTCCTCGA GU γ2B /α | |
| TAGCACACACCAGCCCAGCC CAGTGAGGAGAAGCAAAATT GU α | |
| CCCAGCCCAACCTATTCCAG CCCTCGGCGGGGAGAGGGAA GU α | |
| TCCAGCTCAGCCCAGCCTAA CCCGCGATCAGCTCTCCTGA LN/SP α |
Shown are 20 bp of Ig sequences followed by 20 bp of c-myc. Also given are the tissues where these recombinations were detected and the Ig locus that is involved in the rearrangement.
Abbreviations: PP, Peyer's patches; SP, spleen; GU, gut; OG, mesenteric oil granuloma; ?, the sequence that was joined to c-myc could not be aligned to germline.