Outcomes in older adolescents treated in recent pediatric trials
| Trial . | N of patients . | Age range, y . | Median age, y . | CR, % . | Early death, % . | Death in CR, % . | HSCT, % . | EFS . | OS . | Reference . | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Y . | % . | Y . | % . | |||||||||
| CCG 1961 | 262 | 16-21 | NR | 95 | 2 | 3 | 4 | 5 | 72 | 5 | 78 | 48 |
| DFCI 9101/9501 | 51 | 15-18 | 16.2 | 94 | 4 | 2 | NR | 5 | 78 | 5 | 81 | 49 |
| Total Therapy XV | 45 | 15-18 | NR | 98 | 0 | 7 | 11 | 5 | 86 | 5 | 88 | 51 |
| UKALL 2003 | 229 | 16-24 | NR | 97 | NR | 6 | 6.1 | 5 | 72 | 5 | 76 | 50 |
| FRALLE 2000 | 186 | 15-19 | 16.1 | 96 | 2 | 2 | 12 | 5 | 74 | 5 | 80 | Data on file |
| Trial . | N of patients . | Age range, y . | Median age, y . | CR, % . | Early death, % . | Death in CR, % . | HSCT, % . | EFS . | OS . | Reference . | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Y . | % . | Y . | % . | |||||||||
| CCG 1961 | 262 | 16-21 | NR | 95 | 2 | 3 | 4 | 5 | 72 | 5 | 78 | 48 |
| DFCI 9101/9501 | 51 | 15-18 | 16.2 | 94 | 4 | 2 | NR | 5 | 78 | 5 | 81 | 49 |
| Total Therapy XV | 45 | 15-18 | NR | 98 | 0 | 7 | 11 | 5 | 86 | 5 | 88 | 51 |
| UKALL 2003 | 229 | 16-24 | NR | 97 | NR | 6 | 6.1 | 5 | 72 | 5 | 76 | 50 |
| FRALLE 2000 | 186 | 15-19 | 16.1 | 96 | 2 | 2 | 12 | 5 | 74 | 5 | 80 | Data on file |
CCG, Children’s Cancer Group; DFCI, Dana-Farber Cancer Institute; FRALLE, French Acute Lymphoblastic Leukemia Study Group; NR, not reported; UKALL, United Kingdom Acute Lymphoblastic Leukaemia.