Imaging and clinical predictors of incident overt stroke and recurrent silent infarcts in children with sickle cell anemia and silent cerebral infarcts in the SIT Trial
| . | Odds ratio (95% confidence interval) . | P . |
|---|---|---|
| Prediction of incident overt stroke: non-randomized and randomized children (N = 286) | ||
| Imaging predictors | ||
| FLAIR lesion volume (% of brain) | 9.20 (3.01-28.08) | .001 |
| Gray to white matter FLAIR volume ratio | — | — |
| Percentage of lesion volume inside 90% heat map | — | — |
| Clinical predictors | ||
| Age at registration, years | — | — |
| Steady-state reticulocytes (%) | 1.10 (1.01-1.20) | .008 |
| Parental report of recurrent headaches | — | — |
| Prediction of incident overt stroke and recurrent silent infarcts: randomized children only (N = 196) | ||
| Imaging predictors | ||
| FLAIR lesion volume (% of brain) | — | — |
| Gray to white matter FLAIR volume ratio | — | — |
| Percentage of lesion volume inside 90% heat map | — | — |
| Clinical predictors | ||
| Age at randomization, years | 0.72 (0.56-0.89) | .004 |
| Steady-state reticulocytes (%) | 1.10 (1.01-1.22) | .040 |
| Parental report of recurrent headache | 4.06 (1.43-12.85) | .011 |
| Randomization to transfusion (vs observation) | 0.30 (0.09-0.88) | .036 |
| . | Odds ratio (95% confidence interval) . | P . |
|---|---|---|
| Prediction of incident overt stroke: non-randomized and randomized children (N = 286) | ||
| Imaging predictors | ||
| FLAIR lesion volume (% of brain) | 9.20 (3.01-28.08) | .001 |
| Gray to white matter FLAIR volume ratio | — | — |
| Percentage of lesion volume inside 90% heat map | — | — |
| Clinical predictors | ||
| Age at registration, years | — | — |
| Steady-state reticulocytes (%) | 1.10 (1.01-1.20) | .008 |
| Parental report of recurrent headaches | — | — |
| Prediction of incident overt stroke and recurrent silent infarcts: randomized children only (N = 196) | ||
| Imaging predictors | ||
| FLAIR lesion volume (% of brain) | — | — |
| Gray to white matter FLAIR volume ratio | — | — |
| Percentage of lesion volume inside 90% heat map | — | — |
| Clinical predictors | ||
| Age at randomization, years | 0.72 (0.56-0.89) | .004 |
| Steady-state reticulocytes (%) | 1.10 (1.01-1.22) | .040 |
| Parental report of recurrent headache | 4.06 (1.43-12.85) | .011 |
| Randomization to transfusion (vs observation) | 0.30 (0.09-0.88) | .036 |