Prevalence of age-specific chromosome abnormalities in AML
| Chromosome aberration . | Infants, 0-2 y (%) . | Children, 2-11 y (%) . | Children, 12-17 y (%) . | AYAs, 18-39 y (%) . | Adults, 40-59 y (%) . | Risk category . |
|---|---|---|---|---|---|---|
| t(15;17) | 2 | 5.9 | 11.7 | 12.4 | 8.1 | Favorable |
| t(8;21) | <1 | 17.2 | 13.3 | 7.8 | 4.3 | Favorable |
| Inv(16) | 6.3 | 10 | 8.8 | 5.5 | 4.4 | Favorable |
| Normal karyotype | 14 | 20 | 27 | 44 | 52 | Intermediate |
| t(9;11) | 19.6 | 8.3 | 4.5 | 2.6 | 1.2 | Intermediate |
| 11q23/MLL | 25.2 | 10 | 7.4 | 5.1 | 2.0 | Unfavorable for adults, variable for children |
| Complex karyotype | 14 | 7.0 | 4.3 | 2.3 | 7.8 | Unfavorable for adults |
| Monosomy 7 | <1 | 1.9 | 1.1 | 0.9 | 1.2 | Unfavorable |
| Chromosome 5 abnormalities | <1 | 1.3 | 1.4 | <1 | <1 | Unfavorable |
| 17p abnormalities | 0 | 0 | 0 | 0.2 | 0.3 | Unfavorable for adults |
| 12p abnormalities | 1.5 | 0.4 | 1.1 | 0.5 | 0.2 | Unfavorable for adults |
| t(6;9) | 0 | 0 | 0.5 | 1.4 | 0.3 | Unfavorable for adults |
| Inv(3) | 0 | 0.2 | 0.2 | 1.2 | 0.7 | Unfavorable for adults |
| Chromosome aberration . | Infants, 0-2 y (%) . | Children, 2-11 y (%) . | Children, 12-17 y (%) . | AYAs, 18-39 y (%) . | Adults, 40-59 y (%) . | Risk category . |
|---|---|---|---|---|---|---|
| t(15;17) | 2 | 5.9 | 11.7 | 12.4 | 8.1 | Favorable |
| t(8;21) | <1 | 17.2 | 13.3 | 7.8 | 4.3 | Favorable |
| Inv(16) | 6.3 | 10 | 8.8 | 5.5 | 4.4 | Favorable |
| Normal karyotype | 14 | 20 | 27 | 44 | 52 | Intermediate |
| t(9;11) | 19.6 | 8.3 | 4.5 | 2.6 | 1.2 | Intermediate |
| 11q23/MLL | 25.2 | 10 | 7.4 | 5.1 | 2.0 | Unfavorable for adults, variable for children |
| Complex karyotype | 14 | 7.0 | 4.3 | 2.3 | 7.8 | Unfavorable for adults |
| Monosomy 7 | <1 | 1.9 | 1.1 | 0.9 | 1.2 | Unfavorable |
| Chromosome 5 abnormalities | <1 | 1.3 | 1.4 | <1 | <1 | Unfavorable |
| 17p abnormalities | 0 | 0 | 0 | 0.2 | 0.3 | Unfavorable for adults |
| 12p abnormalities | 1.5 | 0.4 | 1.1 | 0.5 | 0.2 | Unfavorable for adults |
| t(6;9) | 0 | 0 | 0.5 | 1.4 | 0.3 | Unfavorable for adults |
| Inv(3) | 0 | 0.2 | 0.2 | 1.2 | 0.7 | Unfavorable for adults |
Adapted from Creutzig et al2 with permission.