Table 2. Univariate association of... | American Society of Hematology

Table 2.

Univariate association of clinical characteristics, clinical prognostic factors, single miRNAs, and the 3-miRNA classifier with PFS

	Discovery cohort (n = 82)		Independent validation cohort (n = 72)		Entire cohort (n = 154)
Risk factor	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
Sex (male vs female)	0.84 (0.40-1.75)	.64	0.79 (0.33-1.89)	.59	0.84 (0.48-1.47)	.54
Age (>60 vs ≤60 y)	2.05 (0.78-5.38)	.12	0.93 (0.38-2.26)	.88	1.43 (0.77-2.65)	.25
Stage (T1b+T2b vs T1a+T2a)	2.94 (0.40-21.60)	.21	7.11 (0.95-53.4)	.01	5.01 (1.22-20.6)	.004
Treatment (yes vs no)*	1.04 (0.47-2.27)	.93	1.37 (0.52-3.6)	.54	1.16 (0.63-2.12)	.64
CLIPi†
CLIPi group 3 vs 1-2	1.42 (0.69-2.93)	.34	1.41 (0.57-3.45)	.46	1.46 (0.84-2.55)	.18
CLIPi group 2-3 vs 1	1.40 (0.42-4.63)	.57	1.58 (0.53-4.72)	.40	1.58 (0.71-3.52)	.24
Single miRNAs
miR-106b-5p	2.24 (1.49-3.37)	.00009	2.85 (1.49-5.46)	.0007	2.39 (1.72-3.33)	.0000002
miR-148a-3p	2.71 (1.56-4.73)	.0004	1.90 (0.92-3.93)	.07	2.41 (1.57-3.71)	.00005
miR-338-3p	1.64 (1.18-2.28)	.004	1.30 (0.84-2.00)	.24	1.49 (1.14-1.94)	.004
miRNA classifier
miR classifier (low vs high risk)	4.45 (2.08-9.54)	.000065	4.60 (1.75-12)	.006	4.28 (2.45-7.46)	.0000007
miR classifier (risk score)	13.9 (4.38-44.20)	.0000007	17 (3.45-83.60)	.0005	13.5 (5.6-32.7)	.0000000001

	Discovery cohort (n = 82)		Independent validation cohort (n = 72)		Entire cohort (n = 154)
Risk factor	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
Sex (male vs female)	0.84 (0.40-1.75)	.64	0.79 (0.33-1.89)	.59	0.84 (0.48-1.47)	.54
Age (>60 vs ≤60 y)	2.05 (0.78-5.38)	.12	0.93 (0.38-2.26)	.88	1.43 (0.77-2.65)	.25
Stage (T1b+T2b vs T1a+T2a)	2.94 (0.40-21.60)	.21	7.11 (0.95-53.4)	.01	5.01 (1.22-20.6)	.004
Treatment (yes vs no)*	1.04 (0.47-2.27)	.93	1.37 (0.52-3.6)	.54	1.16 (0.63-2.12)	.64
CLIPi†
CLIPi group 3 vs 1-2	1.42 (0.69-2.93)	.34	1.41 (0.57-3.45)	.46	1.46 (0.84-2.55)	.18
CLIPi group 2-3 vs 1	1.40 (0.42-4.63)	.57	1.58 (0.53-4.72)	.40	1.58 (0.71-3.52)	.24
Single miRNAs
miR-106b-5p	2.24 (1.49-3.37)	.00009	2.85 (1.49-5.46)	.0007	2.39 (1.72-3.33)	.0000002
miR-148a-3p	2.71 (1.56-4.73)	.0004	1.90 (0.92-3.93)	.07	2.41 (1.57-3.71)	.00005
miR-338-3p	1.64 (1.18-2.28)	.004	1.30 (0.84-2.00)	.24	1.49 (1.14-1.94)	.004
miRNA classifier
miR classifier (low vs high risk)	4.45 (2.08-9.54)	.000065	4.60 (1.75-12)	.006	4.28 (2.45-7.46)	.0000007
miR classifier (risk score)	13.9 (4.38-44.20)	.0000007	17 (3.45-83.60)	.0005	13.5 (5.6-32.7)	.0000000001

Use of skin-directed therapies (topical corticosteroids, phototherapy, or nitrogen mustard) upon diagnosis. No patients received systemic therapies.

CLIPi group 1 = low risk (0-1 risk factors); CLIPi group 2 = intermediate risk (2 risk factors); CLIPi group 3 = high risk (3-5 risk factors).¹²