The Cox proportional hazards model for risk factors of DVT recurrence: model with categorical fibrin clot properties
| Variable . | HR per . | Univariate . | Multivariate* . | ||
|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | ||
| Age | 1 y | 1.02 (1-1.04) | .017 | 1.02 (0.99-1.04) | .11 |
| Male sex | No/yes | 0.63 (0.40- 0.99) | .045 | 0.72 (0.43-1.20) | .21 |
| BMI | 1 kg/m2 | 1.02 (0.97-1.08) | .449 | — | — |
| Time of anticoagulation | 1 mo | 1.05 (0.99-1.11) | .111 | — | — |
| Unprovoked VTE | No/yes | 1.46 (0.93-2.29) | .100 | — | — |
| Proximal DVT alone | No/yes | 1.19 (0.76-1.87) | .45 | 1.86 (1.13-3.06) | .01 |
| Smoking | No/yes | 0.41 (0.23-0.72) | .001 | 0.54 (0.29-1.02) | .06 |
| Family history of VTE | No/yes | 1.0035 (0.54-1.86) | .99 | 0.58 (0.26-1.24) | .16 |
| Creatinine† | 1 µmol/L | 1.01 (0.99-1.03) | .22 | 0.99 (0.97-1.01) | .24 |
| Glucose† | 1 mmol/L | 1.14 (0.82-1.58) | .45 | 1.04 (0.7-1.52) | .87 |
| CRP | 1 mg/L | 1.16 (1.03-1.30) | .027 | 1.20 (1.04-1.40) | .02 |
| D-dimer | 100 mg/dL | 1.94 (1.6-2.35) | <.001 | 2.05 (1.59-2.66) | <.001 |
| tPA | 1 ng/mL | 0.97 (0.90-1.05) | .42 | — | — |
| PAI-1 | 1 ng/mL | 1.005 (0.97-1.05) | .81 | 0.95 (0.9-1.01) | .09 |
| Peak thrombin | 100 nM | 2.67 (2.03-3.53) | <.0001 | 1.46 (1.09-1.96) | .01 |
| Ks | >7.3 vs ≤7.3 × 10−9 cm2 | 4.06 (2.40-6.89) | <.001 | 2.18 (1.17-4.06) | .01 |
| Lag phase | >41 vs ≤41 s | 3.07 (1.9-4.95) | <.001 | 2.87 (1.66-5.02) | <.001 |
| ΔAbs | ≤0.85 vs >0.85 | 1.69 (1.05-2.72) | .038 | — | — |
| D-Dmax | ≤3.51 vs >3.51 mg/L | 2.71 (1.18-6.26) | .007 | — | — |
| D-Drate | >0.072 vs ≤0.072 mg/L/min | 2.91 (1.73-4.88) | <.0001 | 3.71 (2.03-6.77) | <.001 |
| CLT | ≤96 vs >96 min | 5.91 (3.66-9.54) | <.001 | 3.52 (2.01-6.16) | <.001 |
| Variable . | HR per . | Univariate . | Multivariate* . | ||
|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | ||
| Age | 1 y | 1.02 (1-1.04) | .017 | 1.02 (0.99-1.04) | .11 |
| Male sex | No/yes | 0.63 (0.40- 0.99) | .045 | 0.72 (0.43-1.20) | .21 |
| BMI | 1 kg/m2 | 1.02 (0.97-1.08) | .449 | — | — |
| Time of anticoagulation | 1 mo | 1.05 (0.99-1.11) | .111 | — | — |
| Unprovoked VTE | No/yes | 1.46 (0.93-2.29) | .100 | — | — |
| Proximal DVT alone | No/yes | 1.19 (0.76-1.87) | .45 | 1.86 (1.13-3.06) | .01 |
| Smoking | No/yes | 0.41 (0.23-0.72) | .001 | 0.54 (0.29-1.02) | .06 |
| Family history of VTE | No/yes | 1.0035 (0.54-1.86) | .99 | 0.58 (0.26-1.24) | .16 |
| Creatinine† | 1 µmol/L | 1.01 (0.99-1.03) | .22 | 0.99 (0.97-1.01) | .24 |
| Glucose† | 1 mmol/L | 1.14 (0.82-1.58) | .45 | 1.04 (0.7-1.52) | .87 |
| CRP | 1 mg/L | 1.16 (1.03-1.30) | .027 | 1.20 (1.04-1.40) | .02 |
| D-dimer | 100 mg/dL | 1.94 (1.6-2.35) | <.001 | 2.05 (1.59-2.66) | <.001 |
| tPA | 1 ng/mL | 0.97 (0.90-1.05) | .42 | — | — |
| PAI-1 | 1 ng/mL | 1.005 (0.97-1.05) | .81 | 0.95 (0.9-1.01) | .09 |
| Peak thrombin | 100 nM | 2.67 (2.03-3.53) | <.0001 | 1.46 (1.09-1.96) | .01 |
| Ks | >7.3 vs ≤7.3 × 10−9 cm2 | 4.06 (2.40-6.89) | <.001 | 2.18 (1.17-4.06) | .01 |
| Lag phase | >41 vs ≤41 s | 3.07 (1.9-4.95) | <.001 | 2.87 (1.66-5.02) | <.001 |
| ΔAbs | ≤0.85 vs >0.85 | 1.69 (1.05-2.72) | .038 | — | — |
| D-Dmax | ≤3.51 vs >3.51 mg/L | 2.71 (1.18-6.26) | .007 | — | — |
| D-Drate | >0.072 vs ≤0.072 mg/L/min | 2.91 (1.73-4.88) | <.0001 | 3.71 (2.03-6.77) | <.001 |
| CLT | ≤96 vs >96 min | 5.91 (3.66-9.54) | <.001 | 3.52 (2.01-6.16) | <.001 |