Measures of performance to predict the DVT recurrence during follow-up based on optimal cutoffs investigated in the ROC analysis
| Variable . | Sensitivity, % (95% CI) . | Specificity, % (95% CI) . | PPV, % (95% CI) . | NPV, % (95% CI) . | Positive LR (95% CI) . | Negative LR (95% CI) . |
|---|---|---|---|---|---|---|
| Ks, 7.3 × 10−9 cm2 | 76.62 (65.6-85.5) | 61.47 (54.9- 67.8) | 39. 86 (31.9- 48.2) | 88.75 (82.8- 93.2) | 1.99 (1.62- 2.44) | 0.38 (0.25-0.58) |
| Lag phase, 41 s | 67.53 (55.9- 77.8) | 64.50 (57.9- 70.7) | 38.8 (30.5-47.6) | 85.63 (79.5- 90.5) | 1.90 (1.51- 2.40) | 0.50 (0.36-0.70) |
| ΔAbs, 0.85 | 45.45 (34.1- 57.2) | 70.12 (63.8-76.0) | 33.65 (24.7- 43.6) | 79.41 (73.2- 84.7) | 1.52 (1.11- 2.08) | 0.78 (0.62-0.97) |
| D-Dmax, 3.51 mg/L | 93.51 (85.5- 97.9) | 18.18 (13.4- 23.8) | 27.58 (22.3- 33.4) | 89.36 (76.9- 96.5) | 1.14 (1.05- 1.24) | 0.36 (0.15-0.87) |
| D-Drate, 0.072 mg/L/min | 75.32 (64.2- 84.4) | 51.51 (44.9- 58.1) | 34.11 (27.0- 41.8) | 86.23 (79.3- 91.5) | 1.55 (1.29- 1.87) | 0.48 (0.32-0.72) |
| CLT, 96 min | 71.43 (60.0-81.2) | 79.22 (73.4- 84.3) | 53.39 (43.3- 63.3) | 89.26 (84.2-93.2) | 3.44 (2.58- 4.59) | 0.36 (0.25-0.52) |
| Peak thrombin, 269 nM | 68.83 (57.26-78.91) | 71.00 (64.68-76.76) | 44.17 (35.11-53.52) | 87.23 (81.60-91.65) | 2.37 (1.85-3.05) | 0.44 (0.31-0.62) |
| ETP, 1580.78 nM × min | 62.34 (50.56-73.13) | 65.37 (58.85-71.49) | 37.5 (29.10-46.49) | 83.89 (77.69-88.94) | 1.8 (1.4-2.31) | 0.58 (0.43-0.78) |
| Time to thrombin peak, 6 min | 94.81 (87.23-98.57) | 16.02 (11.54-21.40) | 27.34 (22.09-33.11) | 90.24 (76.87-97.28) | 1.13 (1.05-1.22) | 0.32 (0.12-0.88) |
| Variable . | Sensitivity, % (95% CI) . | Specificity, % (95% CI) . | PPV, % (95% CI) . | NPV, % (95% CI) . | Positive LR (95% CI) . | Negative LR (95% CI) . |
|---|---|---|---|---|---|---|
| Ks, 7.3 × 10−9 cm2 | 76.62 (65.6-85.5) | 61.47 (54.9- 67.8) | 39. 86 (31.9- 48.2) | 88.75 (82.8- 93.2) | 1.99 (1.62- 2.44) | 0.38 (0.25-0.58) |
| Lag phase, 41 s | 67.53 (55.9- 77.8) | 64.50 (57.9- 70.7) | 38.8 (30.5-47.6) | 85.63 (79.5- 90.5) | 1.90 (1.51- 2.40) | 0.50 (0.36-0.70) |
| ΔAbs, 0.85 | 45.45 (34.1- 57.2) | 70.12 (63.8-76.0) | 33.65 (24.7- 43.6) | 79.41 (73.2- 84.7) | 1.52 (1.11- 2.08) | 0.78 (0.62-0.97) |
| D-Dmax, 3.51 mg/L | 93.51 (85.5- 97.9) | 18.18 (13.4- 23.8) | 27.58 (22.3- 33.4) | 89.36 (76.9- 96.5) | 1.14 (1.05- 1.24) | 0.36 (0.15-0.87) |
| D-Drate, 0.072 mg/L/min | 75.32 (64.2- 84.4) | 51.51 (44.9- 58.1) | 34.11 (27.0- 41.8) | 86.23 (79.3- 91.5) | 1.55 (1.29- 1.87) | 0.48 (0.32-0.72) |
| CLT, 96 min | 71.43 (60.0-81.2) | 79.22 (73.4- 84.3) | 53.39 (43.3- 63.3) | 89.26 (84.2-93.2) | 3.44 (2.58- 4.59) | 0.36 (0.25-0.52) |
| Peak thrombin, 269 nM | 68.83 (57.26-78.91) | 71.00 (64.68-76.76) | 44.17 (35.11-53.52) | 87.23 (81.60-91.65) | 2.37 (1.85-3.05) | 0.44 (0.31-0.62) |
| ETP, 1580.78 nM × min | 62.34 (50.56-73.13) | 65.37 (58.85-71.49) | 37.5 (29.10-46.49) | 83.89 (77.69-88.94) | 1.8 (1.4-2.31) | 0.58 (0.43-0.78) |
| Time to thrombin peak, 6 min | 94.81 (87.23-98.57) | 16.02 (11.54-21.40) | 27.34 (22.09-33.11) | 90.24 (76.87-97.28) | 1.13 (1.05-1.22) | 0.32 (0.12-0.88) |
LR, likelihood ratio; NPV negative predictive value; PPV, positive predictive value.